Publisher Summary The first principle of biochemistry is that biological reactions occur in
single steps, each step resulting in some minor modification of the reacting molecules, the …

The induced fit mechanism and conformational changes of some enzymes are reviewed.
Although it is maintained in the literature that induced fit provides specificity, one simple …

Publisher Summary This chapter discusses that the concept that enzymic reactions
demonstrate linear reaction rates and, therefore, linear progress curves, after a very rapid …

This book both suffers and gains from changing fashions. In the decade 1965-1975, a large
number of papers described various allosteric models. When it became apparent how …

Abstract Biochemical Systems Theory (BST) was developed in the late 1960s to explicate
the integrated behavior of intact biochemical systems—specific dynamic behavior as well as …

NADPH oxidase 2 (NOX2) produces the superoxide anion radical (O 2−), which has
functions in both cell signaling and immune defense. NOX2 is a multimeric-protein complex …

Supramolecular Enzyme Organization: Quaternary Structure and Beyond provides a
comprehensive discussion of enzyme interactions. It attempts to place conceptually related …

The activity of an enzyme may be measured by determining the rate of product formation or
substrate used during the enzyme-catalysed reaction. For many enzymes there are several …

Paul M. Anderson abstract: Previous studies have shown that CTP synthetase exists as a
dimer which aggregates to a tetramer in the presence of the substrates ATP and UTP [Long …

Impaired DNA repair activity has been shown to greatly increase rates of cancer clinically. It
has been hypothesized that upregulating repair activity in susceptible individuals may be a …