Nanomaterial (NM) delivery to solid tumors has been the focus of intense research for over a
decade. Classically, scientists have tried to improve NM delivery by employing passive or …

Many efforts have been made to achieve targeted delivery of anticancer drugs to enhance
their efficacy and to reduce their adverse effects. These efforts include the development of …

The use of nanomedicine for antitumor therapy has been extensively investigated for a long
time. Enhanced permeability and retention (EPR) effect-mediated drug delivery is currently …

Cancer involves a collection of diseases with a common trait–dysregulation in cell
proliferation. At present, traditional therapeutic strategies against cancer have limitations in …

The characteristics of the primary tumor blood vessels and the tumor microenvironment drive
the enhanced permeability and retention (EPR) effect, which confers an advantage towards …

Abnormal angiogenesis stands for one of the most striking manifestations of malignant
tumor. The pathologically and structurally abnormal tumor vasculature facilitates a hostile …

All intravenous delivered nanomedicine needs to escape from the blood vessel to exert their
therapeutic efficacy at their designated site of action. Failure to do so increases the …

Nanomedicines including liposomes, micelles, and nanoparticles based on the enhanced
permeability and retention (EPR) effect have become the mainstream for tumor treatment …

The innovative development of nanomedicine has promised effective treatment options
compared to the standard therapeutics for cancer therapy. However, the efficiency of EPR …

The tumor vasculature plays a crucial role in promoting tumor growth and metastasis,
showcasing heterogeneity in terms of tissue composition, functionality, and structural …