Transforming discoveries about cortical microcircuits and gamma oscillations into new treatments for cognitive deficits in schizophrenia

VS Sohal - American Journal of Psychiatry, 2022 - Am Psychiatric Assoc
The major cause of disability in schizophrenia is cognitive impairment, which remains
largely refractory to existing treatments. This reflects the fact that antipsychotics and other …

Gamma oscillations predict pro-cognitive and clinical response to auditory-based cognitive training in schizophrenia

JL Molina, ML Thomas, YB Joshi… - Translational …, 2020 - nature.com
Cognitive impairments are pervasive and disabling features of schizophrenia. Targeted
cognitive training (TCT) is a “bottom-up” cognitive remediation intervention with efficacy for …

Understanding cortical dysfunction in schizophrenia with TMS/EEG

A Vittala, N Murphy, A Maheshwari… - Frontiers in …, 2020 - frontiersin.org
In schizophrenia and related disorders, a deeper mechanistic understanding of neocortical
dysfunction will be essential to developing new diagnostic and therapeutic techniques. To …

Dorsal attention network activity during perceptual organization is distinct in schizophrenia and predictive of cognitive disorganization

BP Keane, B Krekelberg, RD Mill… - European Journal of …, 2023 - Wiley Online Library
Visual shape completion is a canonical perceptual organization process that integrates
spatially distributed edge information into unified representations of objects. People with …

Towards a pragmatic approach to a psychophysiological unit of analysis for mental and brain disorders: an EEG-copeia for neurofeedback

JA Micoulaud-Franchi, JM Batail, T Fovet… - Applied …, 2019 - Springer
This article proposes what we call an “EEG-Copeia” for neurofeedback, like the
“Pharmacopeia” for psychopharmacology. This paper proposes to define an “EEG-Copeia” …

Lithium decreases the effects of neuronal calcium sensor protein 1 in pedunculopontine neurons

S D'Onofrio, FJ Urbano, E Messias… - Physiological …, 2016 - Wiley Online Library
Human postmortem studies reported increased expression of neuronal calcium sensor
protein 1 (NCS‐1) in the brains of some bipolar disorder patients, and reduced or aberrant …

Faster bi-stable visual switching in psychosis

KW Killebrew, HR Moser, AN Grant… - Translational …, 2024 - nature.com
Bi-stable stimuli evoke two distinct perceptual interpretations that alternate and compete for
dominance. Bi-stable perception is thought to be driven at least in part by mutual …

Attentional load effects on beta oscillations in healthy and schizophrenic individuals

S Ghorashi, KM Spencer - Frontiers in Psychiatry, 2015 - frontiersin.org
Attentional deficits are prominent among the cognitive disturbances found in schizophrenia.
Given that schizophrenia is also characterized by abnormalities in high-frequency …

Gamma 神经振荡和信息整合加工

钱浩悦, 黄逸慧, 高湘萍 - 心理科学进展, 2018 - journal.psych.ac.cn
Gamma 神经振荡是一种基础神经活动. 它的特性使其与“信息整合加工” 产生了潜在联系.
已有研究显示, 自下而上的跨通道信息整合与感觉皮层的Gamma 振荡同步化有关; …

[HTML][HTML] Pedunculopontine arousal system physiology—Implications for schizophrenia

E Garcia-Rill, S D'Onofrio, S Mahaffey, V Bisagno… - Sleep Science, 2015 - Elsevier
Schizophrenia is characterized by major sleep/wake disturbances including increased
vigilance and arousal, decreased slow wave sleep, and increased REM sleep drive. Other …