Cancer stem cells: emerging key players in immune evasion of cancers

MML Lei, TKW Lee - Frontiers in cell and developmental biology, 2021 - frontiersin.org
Cancer stem cells (CSCs) are subpopulations of undifferentiated cancer cells within the
tumor bulk that are responsible for tumor initiation, recurrence and therapeutic resistance …

Immune evader cancer stem cells direct the perspective approaches to cancer immunotherapy

H Dianat-Moghadam, A Mahari, R Salahlou… - Stem Cell Research & …, 2022 - Springer
Exploration of tumor immunity leads to the development of immune checkpoint inhibitors and
cell-based immunotherapies which improve the clinical outcomes in several tumor types …

[HTML][HTML] Immunotherapy for targeting cancer stem cells in hepatocellular carcinoma

X Dai, Y Guo, Y Hu, X Bao, X Zhu, Q Fu, H Zhang… - Theranostics, 2021 - ncbi.nlm.nih.gov
The rapid development and remarkable success of checkpoint inhibitors have provided
significant breakthroughs in cancer treatment, including hepatocellular carcinoma (HCC) …

Transarterial chemoembolization combined with immune checkpoint inhibitors and tyrosine kinase inhibitors for unresectable hepatocellular carcinoma: efficacy and …

F Yang, GL Xu, JT Huang, Y Yin, W Xiang… - Frontiers in …, 2022 - frontiersin.org
Background Locoregional therapy combined with systemic therapy can further improve the
prognoses for HCC. However, the efficacy of TACE combined with ICIs and TKIs for HCC …

Epigenetic alterations and mechanisms that drive resistance to targeted cancer therapies

N Wajapeyee, R Gupta - Cancer research, 2021 - AACR
Cancer is a complex disease and cancer cells typically harbor multiple genetic and
epigenetic alterations. Large-scale sequencing of patient-derived cancer samples has …

[HTML][HTML] VEGFR2 activity on myeloid cells mediates immune suppression in the tumor microenvironment

Y Zhang, H Huang, M Coleman, A Ziemys, P Gopal… - JCI insight, 2021 - ncbi.nlm.nih.gov
Angiogenesis, a hallmark of cancer, is induced by vascular endothelial growth factor–A
(hereafter VEGF). As a result, anti-VEGF therapy is commonly used for cancer treatment …

First-line atezolizumab plus bevacizumab versus sorafenib in hepatocellular carcinoma: a cost-effectiveness analysis

CL Chiang, SK Chan, SF Lee, HCW Choi - Cancers, 2021 - mdpi.com
Simple Summary There is a growing body of literature demonstrating high cancer drug costs
relative to the benefits provided to patients treated on a large scale. We examined the cost …

Circulating microRNAs as biomarkers for stratifying different phases of liver cancer progression and response to therapy

L D'Abundo, C Bassi, E Callegari, F Moshiri… - Scientific Reports, 2024 - nature.com
Hepatocellular carcinoma (HCC) is the most common liver cancer and is among the leading
causes of cancer-related death worldwide. There is no reliable biomarker for the early …

Green synthesis of gold nanoparticles from Dendrobium officinale and its anticancer effect on liver cancer

W Zhao, J Li, C Zhong, X Zhang, Y Bao - Drug Delivery, 2021 - Taylor & Francis
A novel gold nanoparticle (Do-AuNP) was successfully synthesized from water extracts of
traditional Chinese medicine Dendrobium officinale (DO) without using any extra chemicals …

Prostaglandin E2 and receptors: Insight into tumorigenesis, tumor progression, and treatment of hepatocellular carcinoma

C Chen, J Guan, X Gu, Q Chu, H Zhu - Frontiers in Cell and …, 2022 - frontiersin.org
Hepatocellular carcinoma (HCC) is a common primary liver cancer with∼ 750,000 annual
incidence rates globally. PGE2, usually known as a pro-inflammatory cytokine, is over …