Abstract RNA polymerase II (Pol II) is the multi-protein complex responsible for transcribing
all protein-coding messenger RNA (mRNA). Most research on gene regulation is focused on …

Eukaryotic cells rely upon dynamic, multifaceted regulation at each step of RNA biogenesis
to maintain mRNA pools and ensure normal protein synthesis. Studies in budding yeast …

The half-life of mRNAs, as well as their translation, increases in proportion to the optimal
codons, indicating a tight coupling of codon-dependent differential translation and …

Gene expression is a highly regulated process that adapts RNAs and proteins content to the
cellular context. Under steady-state conditions, mRNA homeostasis is robustly maintained …

The eukaryotic mRNA life cycle includes transcription, nuclear mRNA export and
degradation. To quantify all these processes simultaneously, we perform thiol-linked …

Abstract mRNA level is controlled by factors that mediate both mRNA synthesis and decay,
including the 5'to 3'exonuclease Xrn1. Here we show that nucleocytoplasmic shuttling of …

Nucleic acid delivery in hard‐to‐transfect macrophages have attracted increasing attention
in diverse applications such as defence against bacterial infection. Regulated by …

Many experiments showed that eukaryotic cells maintain a constant mRNA concentration
upon various perturbations by actively regulating mRNA production and degradation rates …

Many experiments showed that eukaryotic cells maintain a constant mRNA concentration
upon various perturbations by actively regulating transcription and degradation rates, known …

Background Gene transcription by RNA polymerase II is a fundamental process in
eukaryotic cells. The precise regulation of transcription is necessary for cellular growth and …