[HTML][HTML] DNA methylation in the pathogenesis of type 2 diabetes in humans
Abstract Background Type 2 diabetes (T2D) is a multifactorial, polygenic disease caused by
impaired insulin secretion and insulin resistance. Genome-wide association studies (GWAS) …
impaired insulin secretion and insulin resistance. Genome-wide association studies (GWAS) …
The role of beta cell recovery in type 2 diabetes remission
M Suleiman, L Marselli, M Cnop, DL Eizirik… - International journal of …, 2022 - mdpi.com
Type 2 diabetes (T2D) has been considered a relentlessly worsening disease, due to the
progressive deterioration of the pancreatic beta cell functional mass. Recent evidence …
progressive deterioration of the pancreatic beta cell functional mass. Recent evidence …
[HTML][HTML] Persistent or transient human β cell dysfunction induced by metabolic stress: specific signatures and shared gene expression with type 2 diabetes
Pancreatic β cell failure is key to type 2 diabetes (T2D) onset and progression. Here, we
assess whether human β cell dysfunction induced by metabolic stress is reversible, evaluate …
assess whether human β cell dysfunction induced by metabolic stress is reversible, evaluate …
Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D
Most signals detected by genome-wide association studies map to non-coding sequence
and their tissue-specific effects influence transcriptional regulation. However, key tissues …
and their tissue-specific effects influence transcriptional regulation. However, key tissues …
A predictive computational platform for optimizing the design of bioartificial pancreas devices
The delivery of encapsulated islets or stem cell-derived insulin-producing cells (ie,
bioartificial pancreas devices) may achieve a functional cure for type 1 diabetes, but their …
bioartificial pancreas devices) may achieve a functional cure for type 1 diabetes, but their …
Loss of ZnT8 function protects against diabetes by enhanced insulin secretion
A rare loss-of-function allele p. Arg138* in SLC30A8 encoding the zinc transporter 8 (ZnT8),
which is enriched in Western Finland, protects against type 2 diabetes (T2D). We recruited …
which is enriched in Western Finland, protects against type 2 diabetes (T2D). We recruited …
Expression Profile of SARS-CoV-2 Host Receptors in Human Pancreatic Islets Revealed Upregulation of ACE2 in Diabetic Donors
Cellular entry of SARS-CoV-2 is thought to occur through the binding of viral spike S1
protein to ACE2. The entry process involves priming of the S protein by TMPRSS2 and …
protein to ACE2. The entry process involves priming of the S protein by TMPRSS2 and …
Bioengineered pancreas–liver crosstalk in a microfluidic coculture chip identifies human metabolic response signatures in prediabetic hyperglycemia
R Zandi Shafagh, S Youhanna, J Keulen… - Advanced …, 2022 - Wiley Online Library
Aberrant glucose homeostasis is the most common metabolic disturbance affecting one in
ten adults worldwide. Prediabetic hyperglycemia due to dysfunctional interactions between …
ten adults worldwide. Prediabetic hyperglycemia due to dysfunctional interactions between …
Integrated epigenome, whole genome sequence and metabolome analyses identify novel multi-omics pathways in type 2 diabetes: A Middle Eastern study
Background T2D is of high prevalence in the middle east and thus studying its mechanisms
is of a significant importance. Using 1026 Qatar BioBank samples, epigenetics, whole …
is of a significant importance. Using 1026 Qatar BioBank samples, epigenetics, whole …
Pump‐Less, Recirculating Organ‐on‐Chip (rOoC) Platform to Model the Metabolic Crosstalk between Islets and Liver
A Aizenshtadt, C Wang, S Abadpour… - Advanced …, 2024 - Wiley Online Library
Type 2 diabetes mellitus (T2DM), obesity, and metabolic dysfunction‐associated steatotic
liver disease (MASLD) are epidemiologically correlated disorders with a worldwide growing …
liver disease (MASLD) are epidemiologically correlated disorders with a worldwide growing …