Malignant ascites in ovarian cancer: cellular, acellular, and biophysical determinants of molecular characteristics and therapy response
Simple Summary Accumulation of excess fluid in the abdomen typically indicates abnormal
function or disease, such as cancer, in the underlying tissues. This accumulation of fluid, or …
function or disease, such as cancer, in the underlying tissues. This accumulation of fluid, or …
[HTML][HTML] Engineering cancer microenvironments for in vitro 3-D tumor models
The natural microenvironment of tumors is composed of extracellular matrix (ECM), blood
vasculature, and supporting stromal cells. The physical characteristics of ECM as well as the …
vasculature, and supporting stromal cells. The physical characteristics of ECM as well as the …
A three‐dimensional in vitro ovarian cancer coculture model using a high‐throughput cell patterning platform
In vitro 3D cancer models that provide a more accurate representation of disease in vivo are
urgently needed to improve our understanding of cancer pathology and to develop better …
urgently needed to improve our understanding of cancer pathology and to develop better …
Flow induces epithelial-mesenchymal transition, cellular heterogeneity and biomarker modulation in 3D ovarian cancer nodules
Seventy-five percent of patients with epithelial ovarian cancer present with advanced-stage
disease that is extensively disseminated intraperitoneally and prognosticates the poorest …
disease that is extensively disseminated intraperitoneally and prognosticates the poorest …
Oxygen‐sensing methods in biomedicine from the macroscale to the microscale
E Roussakis, Z Li, AJ Nichols… - Angewandte Chemie …, 2015 - Wiley Online Library
Oxygen monitoring has been a topic of exhaustive study given its central role in the
biochemistry of life. The ability to quantify the physiological distribution and real‐time …
biochemistry of life. The ability to quantify the physiological distribution and real‐time …
Synergistic enhancement of carboplatin efficacy with photodynamic therapy in a three-dimensional model for micrometastatic ovarian cancer
Metastatic ovarian cancer (OvCa) frequently recurs due to chemoresistance, highlighting the
need for nonoverlapping combination therapies that mechanistically synergize to eradicate …
need for nonoverlapping combination therapies that mechanistically synergize to eradicate …
An imaging-based platform for high-content, quantitative evaluation of therapeutic response in 3D tumour models
While it is increasingly recognized that three-dimensional (3D) cell culture models
recapitulate drug responses of human cancers with more fidelity than monolayer cultures, a …
recapitulate drug responses of human cancers with more fidelity than monolayer cultures, a …
Modulation of redox metabolism negates cancer-associated fibroblasts-induced treatment resistance in a heterotypic 3D culture platform of pancreatic cancer
The complex interplay between cancer cells and their microenvironment remains a major
challenge in the design and optimization of treatment strategies for pancreatic ductal …
challenge in the design and optimization of treatment strategies for pancreatic ductal …
A combination of visudyne and a lipid‐anchored liposomal formulation of benzoporphyrin derivative enhances photodynamic therapy efficacy in a 3D model for …
A major objective in developing new treatment approaches for lethal tumors is to reduce
toxicity to normal tissues while maintaining therapeutic efficacy. Photodynamic therapy …
toxicity to normal tissues while maintaining therapeutic efficacy. Photodynamic therapy …
Noise and epigenetic inheritance of single-cell division times influence population fitness
B Cerulus, AM New, K Pougach, KJ Verstrepen - Current Biology, 2016 - cell.com
The fitness effect of biological noise remains unclear. For example, even within clonal
microbial populations, individual cells grow at different speeds. Although it is known that the …
microbial populations, individual cells grow at different speeds. Although it is known that the …