The bioactivities of sclareol: A mini review

J Zhou, X Xie, H Tang, C Peng, F Peng - Frontiers in Pharmacology, 2022 - frontiersin.org
Sclareol, a diterpene alcohol isolated from the herbal and flavor plant clary sage (Salvia
sclarea L.), is far-famed as the predominant ingredient in the refined oil of Salvia sclarea (L.) …

Terpenoids with special pharmacological significance: A review

R Jaeger, E Cuny - Natural product communications, 2016 - journals.sagepub.com
Terpenoids are a very prominent class of natural compounds produced in diverse genera of
plants, fungi, algae and sponges. They gained significant pharmaceutical value since …

Antiemetic effects of sclareol, possibly through 5-HT3 and D2 receptor interaction pathways: in-vivo and in-silico studies

MH Bappi, AAS Prottay, K Al-Khafaji, MS Akbor… - Food and Chemical …, 2023 - Elsevier
Background Emesis is a complex physiological phenomenon that serves as a defense
against numerous toxins, stressful situations, adverse medication responses, chemotherapy …

Advances on natural abietane, labdane and clerodane diterpenes as anti-cancer agents: Sources and mechanisms of action

R Acquaviva, GA Malfa, MR Loizzo, J Xiao, S Bianchi… - Molecules, 2022 - mdpi.com
Extensive research over the past decades has identified numerous phytochemicals that
could represent an important source of anti-cancer compounds. There is an immediate need …

Preparation, characterization and anti-proliferative effects of sclareol-loaded solid lipid nanoparticles on A549 human lung epithelial cancer cells

H Hamishehkar, MB Bahadori, S Vandghanooni… - Journal of Drug Delivery …, 2018 - Elsevier
Here, sclareol-loaded solid lipid nanoparticles (sclareol-SLNs) was formulated and tested
for potential geno-cytotoxicity upon A549 lung cancer cells. Sclareol-SLNs was formulated …

Curcumin analogues as possible anti-proliferative & anti-inflammatory agents

AM Katsori, M Chatzopoulou, K Dimas… - European journal of …, 2011 - Elsevier
A series of novel curcumin analogues has been designed, synthesized and tested in vitro/in
vivo as potential multi-target agents. Their anti-proliferative and anti-inflammatory activities …

Sclareol-loaded hyaluronan-coated PLGA nanoparticles: Physico-chemical properties and in vitro anticancer features

D Cosco, R Mare, D Paolino, MC Salvatici… - International journal of …, 2019 - Elsevier
Abstract Sclareol (labd‑14‑ene‑8, 13‑diol), a phytochemical compound belonging to labdane-
type diterpenes, has recently attracted noteworthy attention because of its peculiar …

SCLAREIN (SCLAREol contained in zeIN) nanoparticles: Development and characterization of an innovative natural nanoformulation

A Gagliardi, S Voci, S Bonacci, G Iriti, A Procopio… - International Journal of …, 2021 - Elsevier
Sclareol is a labdane diterpene which carries on a broad range of biological activities.
However, its poor water solubility and bioavailability are the foremost drawbacks that limit its …

Sclareol exhibits anti-inflammatory activity in both lipopolysaccharide-stimulated macrophages and the λ-carrageenan-induced paw edema model

GJ Huang, CH Pan, CH Wu - Journal of Natural Products, 2012 - ACS Publications
Sclareol (1) is a natural fragrance compound used widely in the cosmetic and food
industries. Lipopolysaccharide (LPS)-stimulated RAW264. 7 macrophages and the λ …

A mastic gum extract induces suppression of growth of human colorectal tumor xenografts in immunodeficient mice

K Dimas, S Hatziantoniou, JH Wyche, P Pantazis - in vivo, 2009 - iv.iiarjournals.org
Background: We recently reported that ethanol and hexane extracts of the plant product,
mastic gum (MG), contain constituents which can induce p53-and p21-independent G1 …