[HTML][HTML] Integrating human and environmental health in antibiotic risk assessment: a critical analysis of protection goals, species sensitivity and antimicrobial …

G Le Page, L Gunnarsson, J Snape, CR Tyler - Environment international, 2017 - Elsevier
Antibiotics are vital in the treatment of bacterial infectious diseases but when released into
the environment they may impact non-target organisms that perform vital ecosystem services …

[HTML][HTML] Human health risk assessment for contaminated sites: A retrospective review

S Zhang, Y Han, J Peng, Y Chen, L Zhan, J Li - Environment International, 2023 - Elsevier
Soil contamination is a serious global hazard as contaminants can migrate to the human
body through the soil, water, air, and food, threatening human health. Human Health Risk …

[HTML][HTML] Applying adverse outcome pathways (AOPs) to support integrated approaches to testing and assessment (IATA)

KE Tollefsen, S Scholz, MT Cronin, SW Edwards… - Regulatory Toxicology …, 2014 - Elsevier
Chemical regulation is challenged by the large number of chemicals requiring assessment
for potential human health and environmental impacts. Current approaches are too resource …

The fish embryo test (FET): origin, applications, and future

T Braunbeck, B Kais, E Lammer, J Otte… - … Science and Pollution …, 2015 - Springer
Originally designed as an alternative for the acute fish toxicity test according to, eg, OECD
TG 203, the fish embryo test (FET) with the zebrafish (Danio rerio) has been optimized …

[HTML][HTML] OECD validation study to assess intra-and inter-laboratory reproducibility of the zebrafish embryo toxicity test for acute aquatic toxicity testing

F Busquet, R Strecker, JM Rawlings… - Regulatory Toxicology …, 2014 - Elsevier
The OECD validation study of the zebrafish embryo acute toxicity test (ZFET) for acute
aquatic toxicity testing evaluated the ZFET reproducibility by testing 20 chemicals at 5 …

[HTML][HTML] Occurrence, hazard, and risk of psychopharmaceuticals and illicit drugs in European surface waters

CJE Davey, MHS Kraak, A Praetorius, TL Ter Laak… - Water Research, 2022 - Elsevier
This study aimed to provide insights into the risk posed by psychopharmaceuticals and illicit
drugs in European surface waters, and to identify current knowledge gaps hampering this …

Applicability of the fish embryo acute toxicity (FET) test (OECD 236) in the regulatory context of Registration, Evaluation, Authorisation, and Restriction of Chemicals …

M Sobanska, S Scholz, AM Nyman… - Environmental …, 2018 - Wiley Online Library
Abstract In 2013 the Organisation for Economic Co‐operation and Development (OECD) test
guideline (236) for fish embryo acute toxicity (FET) was adopted. It determines the acute …

In silico prediction of physicochemical properties of environmental chemicals using molecular fingerprints and machine learning

Q Zang, K Mansouri, AJ Williams… - Journal of chemical …, 2017 - ACS Publications
There are little available toxicity data on the vast majority of chemicals in commerce. High-
throughput screening (HTS) studies, such as those being carried out by the US …

Fish embryo toxicity test: Identification of compounds with weak toxicity and analysis of behavioral effects to improve prediction of acute toxicity for neurotoxic …

N Klüver, M König, J Ortmann… - … science & technology, 2015 - ACS Publications
The fish embryo toxicity test has been proposed as an alternative for the acute fish toxicity
test, but concerns have been raised for its predictivity given that a few compounds have …

Hypo-or hyperactivity of zebrafish embryos provoked by neuroactive substances: a review on how experimental parameters impact the predictability of behavior …

A Ogungbemi, D Leuthold, S Scholz… - Environmental Sciences …, 2019 - Springer
Tests with zebrafish embryos have gained wide acceptance as an alternative test model for
drug development and toxicity testing. In particular, the behavioral response of the zebrafish …