Single‐cell transcriptome atlas of human mesenchymal stem cells exploring cellular heterogeneity

Z Wang, C Chai, R Wang, Y Feng… - Clinical and …, 2021 - Wiley Online Library
Background The heterogeneity of mesenchymal stem cells (MSCs) is poorly understood,
thus limiting clinical application and basic research reproducibility. Advanced single‐cell …

[HTML][HTML] A review of FGF signaling in palate development

M Weng, Z Chen, Q Xiao, R Li, Z Chen - Biomedicine & Pharmacotherapy, 2018 - Elsevier
The fibroblast growth factors (FGFs) play a critical role during palatogenesis by mediating a
variety of cellular responses. Extensive epidemiological and genetic studies over several …

Development and evolution of the vestibular apparatuses of the inner ear

K Mackowetzky, KH Yoon, EJ Mackowetzky… - Journal of …, 2021 - Wiley Online Library
The vertebrate inner ear is a labyrinthine sensory organ responsible for perceiving sound
and body motion. While a great deal of research has been invested in understanding the …

Structural basis for specific DNA sequence motif recognition by the TFAP2 transcription factors

K Liu, Y Xiao, L Gan, W Li, J Zhang… - Nucleic Acids …, 2023 - academic.oup.com
The TFAP2 family regulates gene expression during differentiation, development, and
organogenesis, and includes five homologs in humans. They all possess a highly conserved …

Variability in cochlear implantation outcomes in a large German cohort with a genetic etiology of hearing loss

A Tropitzsch, T Schade-Mann, P Gamerdinger… - Ear and …, 2023 - journals.lww.com
Objectives: The variability in outcomes of cochlear implantation is largely unexplained, and
clinical factors are not sufficient for predicting performance. Genetic factors have been …

Docosahexaenoic acid (DHA) is a driving force regulating gene expression in bluefin tuna (Thunnus thynnus) larvae development

W Koven, E Yanowski, L Gardner, O Nixon, B Block - Scientific Reports, 2024 - nature.com
This study elucidated the role of DHA-modulated genes in the development and growth of
Atlantic bluefin tuna (Thunnus thynnus) larvae ingesting increasing levels of DHA in their …

Tfap2a is a novel gatekeeper of nephron differentiation during kidney development

BE Chambers, GF Gerlach, EG Clark… - …, 2019 - journals.biologists.com
Renal functional units known as nephrons undergo patterning events during development
that create a segmental array of cellular compartments with discrete physiological identities …

Differential Methylation Profile in Fragile X Syndrome-Prone Offspring Mice after in Utero Exposure to Lactobacillus Reuteri

RR AlOlaby, M Zafarullah, M Barboza, G Peng… - Genes, 2022 - mdpi.com
Environmental factors such as diet, gut microbiota, and infections have proven to have a
significant role in epigenetic modifications. It is known that epigenetic modifications may …

A conserved HOTAIRM1-HOXA1 regulatory axis contributes early to neuronal differentiation

D Segal, S Coulombe, J Sim, J Dostie - RNA biology, 2023 - Taylor & Francis
ABSTRACT HOTAIRM1 is unlike most long non-coding RNAs in that its sequence is highly
conserved across mammals. Such evolutionary conservation points to it having a role in key …

[HTML][HTML] sox2 and sox3 Play unique roles in development of hair cells and neurons in the zebrafish inner ear

Y Gou, S Vemaraju, EM Sweet, HJ Kwon… - Developmental biology, 2018 - Elsevier
Formation of neural and sensory progenitors in the inner ear requires Sox2 in mammals,
and in other species is thought to rely on both Sox2 and Sox3. How Sox2 and/or Sox3 …