Neutrophils are innate immune phagocytes that have a central role in immune defence. Our
understanding of the role of neutrophils in pathogen clearance, immune regulation and …

Glutathione is a remarkably functional molecule with diverse features, which include being
an antioxidant, a regulator of DNA synthesis and repair, a protector of thiol groups in …

Citrullinating enzymes (peptidylarginine deiminases, PADs) are tightly controlled to limit
their hyperactivation. Calcium and redox conditions are important regulators of PAD activity …

NETosis, an antimicrobial form of neutrophil cell death, is considered a primary source of
citrullinated autoantigens in rheumatoid arthritis (RA) and immunogenic DNA in systemic …

Background: Peptidyl arginine deiminase 4 (PAD4) is an enzyme that converts arginine into
citrulline. PAD4 is expressed in neutrophils that, when activated, can drive the formation of …

Neutrophils are produced in the bone marrow and then patrol blood vessels from which they
can be rapidly recruited to a site of infection. Neutrophils bind, engulf, and efficiently kill …

Peptidylarginine deiminases (PADs) are calcium-dependent enzymes that mediate
citrullination, an irreversible post-translational modification (PTM). PAD enzymes have …

Under conditions of cellular stress, proteins can be post-translationally modified causing
them to be recognized by the immune system. One such stress-induced post-translational …

Neutrophils can release their chromatin to form neutrophil extracellular traps (NETs), a
process known as NETosis. Although NET formation can be induced by various stimuli …

Deep venous thrombosis (DVT) is a part of venous thromboembolism (VTE) that clinically
manifests as swelling and pain in the lower limbs. The most serious clinical complication of …