microRNAs biogenesis, functions and role in tumor angiogenesis
T Annese, R Tamma, M De Giorgis, D Ribatti - Frontiers in oncology, 2020 - frontiersin.org
microRNAs (miRNAs) are small non-coding RNA molecules, evolutionary conserved. They
target more than one mRNAs, thus influencing multiple molecular pathways, but also …
target more than one mRNAs, thus influencing multiple molecular pathways, but also …
Role of RUNX1 in hematological malignancies
R Sood, Y Kamikubo, P Liu - … Journal of the American Society of …, 2017 - ashpublications.org
RUNX1 is a member of the core-binding factor family of transcription factors and is
indispensable for the establishment of definitive hematopoiesis in vertebrates. RUNX1 is …
indispensable for the establishment of definitive hematopoiesis in vertebrates. RUNX1 is …
RNA demethylase ALKBH5 selectively promotes tumorigenesis and cancer stem cell self-renewal in acute myeloid leukemia
Summary N 6-methyladenosine (m 6 A), the most abundant internal modification in mRNA,
has been implicated in tumorigenesis. As an m 6 A demethylase, ALKBH5 has been shown …
has been implicated in tumorigenesis. As an m 6 A demethylase, ALKBH5 has been shown …
The miR-17/92 cluster: a comprehensive update on its genomics, genetics, functions and increasingly important and numerous roles in health and disease
E Mogilyansky, I Rigoutsos - Cell Death & Differentiation, 2013 - nature.com
Abstract The miR-17/92 cluster is among the best-studied microRNA clusters. Interest in the
cluster and its members has been increasing steadily and the number of publications has …
cluster and its members has been increasing steadily and the number of publications has …
Role of microRNAs, circRNAs and long noncoding RNAs in acute myeloid leukemia
Acute myeloid leukemia (AML) is a malignant tumor of the immature myeloid hematopoietic
cells in the bone marrow (BM). It is a highly heterogeneous disease, with rising morbidity …
cells in the bone marrow (BM). It is a highly heterogeneous disease, with rising morbidity …
Targeting microRNAs in cancer: rationale, strategies and challenges
MicroRNAs (miRNAs) are evolutionarily conserved small non-coding RNAs that regulate
gene expression. Early studies have shown that miRNA expression is deregulated in cancer …
gene expression. Early studies have shown that miRNA expression is deregulated in cancer …
Physiological and pathological roles for microRNAs in the immune system
Mammalian microRNAs (miRNAs) have recently been identified as important regulators of
gene expression, and they function by repressing specific target genes at the post …
gene expression, and they function by repressing specific target genes at the post …
miR-126 regulates distinct self-renewal outcomes in normal and malignant hematopoietic stem cells
To investigate miRNA function in human acute myeloid leukemia (AML) stem cells (LSC), we
generated a prognostic LSC-associated miRNA signature derived from functionally …
generated a prognostic LSC-associated miRNA signature derived from functionally …
miR-146 and miR-155: two key modulators of immune response and tumor development
U Testa, E Pelosi, G Castelli, C Labbaye - Non-coding RNA, 2017 - mdpi.com
MicroRNAs (miRNAs or miRs) are a class of evolutionarily-conserved small, regulatory non-
coding RNAs, 19–3 nucleotides in length, that negatively regulate protein coding gene …
coding RNAs, 19–3 nucleotides in length, that negatively regulate protein coding gene …
Molecular genetics of adult acute myeloid leukemia: prognostic and therapeutic implications
G Marcucci, T Haferlach, H Döhner - Journal of Clinical Oncology, 2011 - ascopubs.org
Molecular analyses of leukemic blasts from patients with acute myeloid leukemia (AML)
have revealed a striking heterogeneity with regard to the presence of acquired gene …
have revealed a striking heterogeneity with regard to the presence of acquired gene …