Engineering innovations in medicine and biology: Revolutionizing patient care through mechanical solutions
The overlap between mechanical engineering and medicine is expanding more and more
over the years. Engineers are now using their expertise to design and create functional …
over the years. Engineers are now using their expertise to design and create functional …
Expanding landscape of coronary microvascular disease in co-morbid conditions: Metabolic disease and beyond
PE McCallinhart, AR Chade, SB Bender… - Journal of Molecular and …, 2024 - Elsevier
Coronary microvascular disease (CMD) and impaired coronary blood flow control are
defects that occur early in the pathogenesis of heart failure in cardiometabolic conditions …
defects that occur early in the pathogenesis of heart failure in cardiometabolic conditions …
Sex differences in coronary microvascular resistance measured by a computational fluid dynamics model
Background Increased coronary microvascular resistance (CMVR) is associated with
coronary microvascular dysfunction (CMD). Although CMD is more common in women, sex …
coronary microvascular dysfunction (CMD). Although CMD is more common in women, sex …
[HTML][HTML] Personalised parameter estimation of the cardiovascular system: Leveraging data assimilation and sensitivity analysis
Detailed models of dynamical systems used in the life sciences may include hundreds of
state variables and many input parameters, often with physical meanings. Therefore …
state variables and many input parameters, often with physical meanings. Therefore …
[HTML][HTML] Evaluation of models of sequestration flow in coronary arteries—Physiology versus anatomy?
Background: Myocardial ischaemia results from insufficient coronary blood flow. Computed
virtual fractional flow reserve (vFFR) allows quantification of proportional flow loss without …
virtual fractional flow reserve (vFFR) allows quantification of proportional flow loss without …
Main Coronary Flow Calculation With the Assistance of Physiological Side Branch Flow
Objective: Fractional flow reserve (FFR) derived from coronary angiography, referred to as
ICA-FFR, is a less-invasive alternative for invasive FFR measurement based on …
ICA-FFR, is a less-invasive alternative for invasive FFR measurement based on …
Changes in Myocardial Blood Flow and Microvascular Resistance in Patients with Coronary Artery Disease Undergoing Transcatheter Aortic Valve Implantation
BackgroundSevere aortic stenosis (AS) causes a pathophysiological cascade, which
impairs myocardial blood flow. This effect is exacerbated in the presence of coronary …
impairs myocardial blood flow. This effect is exacerbated in the presence of coronary …
Derivation and Sensitivity Analysis of a Novel One-Dimensional Model of Coronary Blood Flow Accounting for Vessel Taper & Boundary Slip
Background: Ischaemic heart disease (IHD) results from insufficient coronary blood flow.
Computational models of coronary flow allow quantification of virtual fractional flow reserve …
Computational models of coronary flow allow quantification of virtual fractional flow reserve …
The Impact of Experimental Designs & System Sloppiness on the Personalisation Process: A Cardiovascular Perspective
To employ a reduced-order cardiovascular model as a digital twin for personalised
medicine, it is essential to understand how uncertainties in the model's input parameters …
medicine, it is essential to understand how uncertainties in the model's input parameters …