Our understanding of the role of myeloid-derived suppressor cells (MDSCs) in cancer is
becoming increasingly complex. In addition to their eponymous role in suppressing immune …

Myeloid-derived suppressor cells (MDSCs) contribute to the induction of an immune
suppressive/anergic, tumor permissive environment. MDSCs act as immunosuppression …

Purpose: Pelareorep is an intravenously delivered oncolytic reovirus that can induce a T-cell–
inflamed phenotype in pancreatic ductal adenocarcinoma (PDAC). Tumor tissues from …

Oncolytic viruses (OVs) represent a new class of cancer immunotherapeutics. Administration
of OVs to cancer-bearing hosts induces two distinct immunities: antiviral and antitumor …

Immuno-oncology (IO) has been an active area of oncology research. Following US FDA
approval of the first immune checkpoint inhibitor (ICI), ipilimumab (human IgG1 k anti-CTLA …

The tumor microenvironment (TME) is a complex and heterogeneous environment
composed of cancer cells, tumor stroma, a mixture of tissue-resident and infiltrating immune …

Oncolytic viruses (OVs) are viral strains that can infect and kill malignant cells while spare
their normal counterparts. OVs can access cells through binding to receptors on their surface …

Pelareorep causes oncolysis in tumor cells with activated Ras. We hypothesized that
pelareorep would have efficacy and immunomodulatory activity in metastatic pancreatic …

Simple Summary Within this review article the authors provide an unbiased review of the
oncolytic virus, reovirus, clinically formulated as pelareorep. In particular, the authors …

Reovirus is a double-stranded RNA virus with demonstrated oncolysis or preferential
replication in cancer cells. The oncolytic properties of reovirus appear to be dependent, in …