Hyperpolarized water as universal sensitivity booster in biomolecular NMR

C Hilty, D Kurzbach, L Frydman - Nature protocols, 2022 - nature.com
NMR spectroscopy is the only method to access the structural dynamics of biomolecules at
high (atomistic) resolution in their native solution state. However, this method's low …

Practical dissolution dynamic nuclear polarization

SJ Elliott, Q Stern, M Ceillier, T El Daraï… - Progress in Nuclear …, 2021 - Elsevier
This review article intends to provide insightful advice for dissolution-dynamic nuclear
polarization in the form of a practical handbook. The goal is to aid research groups to …

Overhauser enhanced liquid state nuclear magnetic resonance spectroscopy in one and two dimensions

M Levien, L Yang, A van der Ham, M Reinhard… - Nature …, 2024 - nature.com
Nuclear magnetic resonance (NMR) is fundamental in the natural sciences, from chemical
analysis and structural biology, to medicine and physics. Despite its enormous …

13C Direct Detected NMR for Challenging Systems

IC Felli, R Pierattelli - Chemical Reviews, 2022 - ACS Publications
Thanks to recent improvements in NMR spectrometer hardware and pulse sequence design,
modern 13C NMR has become a useful tool for biomolecular applications. The complete …

Application and methodology of dissolution dynamic nuclear polarization in physical, chemical and biological contexts

S Jannin, JN Dumez, P Giraudeau… - Journal of Magnetic …, 2019 - Elsevier
Dissolution dynamic nuclear polarization (d-DNP) is a versatile method to enhance nuclear
magnetic resonance (NMR) spectroscopy. It boosts signal intensities by four to five orders of …

Toward protein NMR at physiological concentrations by hyperpolarized water—Finding and mapping uncharted conformational spaces

LM Epasto, K Che, F Kozak, A Selimovic… - Science …, 2022 - science.org
Nuclear magnetic resonance (NMR) spectroscopy is a key method for determining the
structural dynamics of proteins in their native solution state. However, the low sensitivity of …

Spontaneous enhancement of magnetic resonance signals using a RASER

S Korchak, L Kaltschnee, R Dervisoglu… - Angewandte …, 2021 - Wiley Online Library
Nuclear magnetic resonance is usually drastically limited by its intrinsically low sensitivity:
Only a few spins contribute to the overall signal. To overcome this limitation …

Hyperpolarized water through dissolution dynamic nuclear polarization with UV-generated radicals

AC Pinon, A Capozzi… - Communications Chemistry, 2020 - nature.com
In recent years, hyperpolarization of water protons via dissolution Dynamic Nuclear
Polarization (dDNP) has attracted increasing interest in the magnetic resonance community …

[图书][B] Handbook of high field dynamic nuclear polarization

VK Michaelis, RG Griffin, B Corzilius, S Vega - 2019 - books.google.com
Addresses Dynamic Nuclear Polarization (DNP) as a technique for sensitivity-enhancement
in solid-state NMR spectroscopy This comprehensive handbook is a compendium of the …

Cross-Polarization of Insensitive Nuclei from Water Protons for Detection of Protein–Ligand Binding

N Pradhan, C Hilty - Journal of the American Chemical Society, 2024 - ACS Publications
Hyperpolarization derived from water protons enhances the NMR signal of 15N nuclei in a
small molecule, enabling the sensitive detection of a protein–ligand interaction. The water …