The recent genomic characterization of cancers has revealed recurrent somatic point
mutations and copy number changes affecting genes encoding RNA splicing factors. Initial …

Several bacterial fermentation products and their synthetic derivatives display antitumour
activities and bind tightly to components of the spliceosome, which is the complex molecular …

Clonal hemopoiesis driven by leukemia-associated gene mutations can occur without
evidence of a blood disorder. To investigate this phenomenon, we interrogated 15 mutation …

Older adults with acute myeloid leukemia (AML) who are not fit for standard chemotherapy
historically have poor outcomes. Approximately 12–15% of older patients with AML harbor …

Serine/arginine-rich splicing factor 2 (SRSF2) is an RNA-binding protein that plays important
roles in splicing of mRNA precursors. SRSF2 mutations are frequently found in patients with …

Somatic mutations in the spliceosome gene ZRSR2—located on the X chromosome—are
associated with myelodysplastic syndrome (MDS). ZRSR2 is involved in the recognition of …

Hypomethylating agents (HMAs) improve survival in patients with higher-risk
myelodysplastic syndromes (MDS) but are less well-studied in lower-risk disease. We …

Recent advances in high‐throughput sequencing technologies have unexpectedly revealed
that somatic mutations of splicing factor genes frequently occurred in several types of …

Background Mutations in isocitrate dehydrogenase-2 (IDH2) occur in around 5% of patients
with myelodysplastic syndromes. Neomorphic activity of mutant IDH2 proteins results in …

Recent high-throughput genome-wide sequencing studies have identified recurrent somatic
mutations in myeloid neoplasms. An epigenetic regulator, Additional sex combs-like 1 …