Knee osteoarthritis: a review of pathogenesis and state-of-the-art non-operative therapeutic considerations

D Primorac, V Molnar, E Rod, Ž Jeleč, F Čukelj… - Genes, 2020 - mdpi.com
Being the most common musculoskeletal progressive condition, osteoarthritis is an
interesting target for research. It is estimated that the prevalence of knee osteoarthritis (OA) …

[HTML][HTML] Recent advances in the treatment of osteoarthritis

S Grässel, D Muschter - F1000Research, 2020 - ncbi.nlm.nih.gov
Osteoarthritis (OA) is one of the most debilitating diseases and is associated with a high
personal and socioeconomic burden. So far, there is no therapy available that effectively …

The development of disease-modifying therapies for osteoarthritis (DMOADs): the evidence to date

WM Oo, C Little, V Duong, DJ Hunter - Drug Design, Development …, 2021 - Taylor & Francis
Osteoarthritis (OA) is a complex heterogeneous articular disease with multiple joint tissue
involvement of varying severity and no regulatory-agency-approved disease-modifying …

Inflammatory signaling sensitizes Piezo1 mechanotransduction in articular chondrocytes as a pathogenic feed-forward mechanism in osteoarthritis

W Lee, RJ Nims, A Savadipour… - Proceedings of the …, 2021 - National Acad Sciences
Osteoarthritis (OA) is a painful and debilitating condition of synovial joints without any
disease-modifying therapies [AM Valdes, TD Spector, Nat. Rev. Rheumatol. 7, 23–32 …

Efficacy and Safety of Curcumin and Curcuma longa Extract in the Treatment of Arthritis: A Systematic Review and Meta-Analysis of Randomized Controlled Trial

L Zeng, T Yang, K Yang, G Yu, J Li, W Xiang… - Frontiers in …, 2022 - frontiersin.org
Background Modern pharmacological research found that the chemical components of
Curcuma longa L. are mainly curcumin and turmeric volatile oil. Several recent randomized …

Management of osteoarthritis: expert opinion on NSAIDs

A Magni, P Agostoni, C Bonezzi, G Massazza, P Menè… - Pain and therapy, 2021 - Springer
Osteoarthritis (OA) is a leading cause of disability among older adults worldwide. Treatment
aims are to alleviate inflammatory pain and improve physical function through non …

Osteoarthritis: pathogenesis, animal models, and new regenerative therapies

T Szponder, M Latalski, A Danielewicz, K Krać… - Journal of Clinical …, 2022 - mdpi.com
Osteoarthritis (OA) is a chronic, progressive, multifactorial disease resulting in a progressive
loss of articular cartilage structure and function that is most common in middle-aged and …

Therapeutic potential in rheumatic diseases of extracellular vesicles derived from mesenchymal stromal cells

GM Bertolino, M Maumus, C Jorgensen… - Nature Reviews …, 2023 - nature.com
The incidence of rheumatic diseases such as rheumatoid arthritis and osteoarthritis and
injuries to articular cartilage that lead to osteochondral defects is predicted to rise as a result …

Inhibition of fibroblast activation protein ameliorates cartilage matrix degradation and osteoarthritis progression

A Fan, G Wu, J Wang, L Lu, J Wang, H Wei, Y Sun… - Bone Research, 2023 - nature.com
Fibroblast activation protein (Fap) is a serine protease that degrades denatured type I
collagen, α2-antiplasmin and FGF21. Fap is highly expressed in bone marrow stromal cells …

Classification of four distinct osteoarthritis subtypes with a knee joint tissue transcriptome atlas

C Yuan, Z Pan, K Zhao, J Li, Z Sheng, X Yao, H Liu… - Bone research, 2020 - nature.com
The limited molecular classifications and disease signatures of osteoarthritis (OA) impede
the development of prediagnosis and targeted therapeutics for OA patients. To classify and …