The endothelium plays important roles in modulating vascular tone by synthesizing and
releasing a variety of endothelium-derived relaxing factors, including vasodilator …

The endothelium can evoke relaxations of the underlying vascular smooth muscle, by
releasing vasodilator substances. The best‐characterized endothelium‐derived relaxing …

Obesity is causally linked with the development of cardiovascular disorders. Accumulating
evidence indicates that cardiovascular disease is the collateral damage of obesity-driven …

The heart is uniquely responsible for providing its own blood supply through the coronary
circulation. Regulation of coronary blood flow is quite complex and, after over 100 years of …

Objective—Ceramides are molecular lipids implicated in apoptosis, inflammation, obesity,
and insulin resistance. An earlier study reported that ceramides were associated with fatal …

Tobacco smoking is a major risk factor for cardiovascular disease and hypertension. It is
associated with the oxidative stress and induces metabolic reprogramming, altering …

The microcirculation is responsible for orchestrating adjustments in vascular tone to match
local tissue perfusion with oxygen demand. Beyond this metabolic dilation, the …

Growing evidence suggests that ceramides play an important role in the development of
atherosclerotic and valvular heart disease. Ceramides are biologically active sphingolipids …

The major factors determining myocardial perfusion and oxygen delivery have been
elucidated over the past several decades, and this knowledge has been incorporated into …

Background: Experimental evidence suggests a key role of SIRT1 (silent information
regulator 1) in age-and metabolic-related vascular dysfunction. Whether these effects hold …