Recent progress in enzymatic protein labelling techniques and their applications

Y Zhang, KY Park, KF Suazo… - Chemical Society Reviews, 2018 - pubs.rsc.org
Protein-based conjugates are valuable constructs for a variety of applications. Conjugation
of proteins to fluorophores is commonly used to study their cellular localization and the …

Hybrid Small-Molecule/Protein Fluorescent Probes

M Minoshima, SI Reja, R Hashimoto, K Iijima… - Chemical …, 2024 - ACS Publications
Hybrid small-molecule/protein fluorescent probes are powerful tools for visualizing protein
localization and function in living cells. These hybrid probes are constructed by diverse site …

Microtubules and their role in cellular stress in cancer

AL Parker, M Kavallaris, JA McCarroll - Frontiers in oncology, 2014 - frontiersin.org
Microtubules are highly dynamic structures, which consist of α-and β-tubulin heterodimers,
and are involved in cell movement, intracellular trafficking, and mitosis. In the context of …

Fundamental mechanisms of the cell death caused by nitrosative stress

F Wang, Q Yuan, F Chen, J Pang, C Pan… - Frontiers in Cell and …, 2021 - frontiersin.org
Nitrosative stress, as an important oxygen metabolism disorder, has been shown to be
closely associated with cardiovascular diseases, such as myocardial ischemia/reperfusion …

NO-dependent protein nitration: a cell signaling event or an oxidative inflammatory response?

FJ Schopfer, PRS Baker, BA Freeman - Trends in biochemical sciences, 2003 - cell.com
Tyrosine nitration is becoming increasingly recognized as a prevalent, functionally
significant post-translational protein modification that serves as an indicator of nitric oxide …

The detyrosination/re-tyrosination cycle of tubulin and its role and dysfunction in neurons and cardiomyocytes

C Sanyal, N Pietsch, SR Rios, L Peris, L Carrier… - Seminars in cell & …, 2023 - Elsevier
Among the variety of post-translational modifications to which microtubules are subjected,
the detyrosination/re-tyrosination cycle is specific to tubulin. It is conserved by evolution and …

Protein tyrosine nitration—an update

H Ischiropoulos - Archives of biochemistry and biophysics, 2009 - Elsevier
Tyrosine nitration is a covalent post-translational protein modification derived from the
reaction of proteins with nitrating agents. Tyrosine nitration has been used as a marker of …

Low expression of human tubulin tyrosine ligase and suppressed tubulin tyrosination/detyrosination cycle are associated with impaired neuronal differentiation in …

C Kato, K Miyazaki, A Nakagawa… - … journal of cancer, 2004 - Wiley Online Library
Neuroblastoma (NBL), one of the most common childhood solid tumors, has a distinct nature
in different prognostic subgroups. However, the precise mechanism underlying this …

TTLL12 has a potential oncogenic activity, suppression of ligation of nitrotyrosine to the C-terminus of detyrosinated α-tubulin, that can be overcome by molecules …

A Deshpande, J Brants, C Wasylyk, O van Hooij… - PloS one, 2024 - journals.plos.org
Tubulin tyrosine ligase 12 (TTLL12) is a promising target for therapeutic intervention since it
has been implicated in tumour progression, the innate immune response to viral infection …

Nitric oxide signalling via cytoskeleton in plants

AI Yemets, YA Krasylenko, DI Lytvyn, YA Sheremet… - Plant Science, 2011 - Elsevier
Nitric oxide (NO) in plant cell mediates processes of growth and development starting from
seed germination to pollination, as well as biotic and abiotic stress tolerance. However …