Osteoclast over-activation leads to bone loss and chloride homeostasis is fundamental
importance for osteoclast function. The calcium-activated chloride channel Anoctamin 1 …

Cellular Ca 2+ signaling functions as one of the most common second messengers of
various signal transduction pathways in cells and mediates a number of physiological roles …

Myenteric plexus interstitial cells of Cajal (ICC-MY) in the small intestine are Kit+ electrical
pacemakers that express the Ano1/TMEM16A Ca2+-activated Cl–channel, whose functions …

Key points The internal anal sphincter develops tone important for maintaining high anal
pressure and continence. Controversy exists regarding the mechanisms underlying tone …

Maintenance of fecal continence requires a continuous or basal tone of the internal anal
sphincter (IAS). Paradoxically, the basal tone results largely from high-frequency rhythmic …

Background Allergic inflammation has long been implicated in asthmatic
hyperresponsiveness of airway smooth muscle (ASM), but its underlying mechanism …

Human lymphatic vessels are myogenically active and respond to sympathetic stimulation.
The role of various cations in this behavior has recently been investigated, but whether the …

Slow transit constipation (STC) is the most common type of functional constipation. Drugs
with good effects and few side effects are urgently needed form the treatment of STC …

IT IS WELL KNOWN that smooth muscle contraction, whether spontaneous or following
pharmacological stimulation, occurs in two phases: the initial phasic followed by the tonic …

Summary Transmembrane protein 16A (TMEM16A) localizes at plasma membrane and
controls chloride influx in various type of cells. We here showed an intracellular localization …