Microfluidics‐based 3D cell culture models: Utility in novel drug discovery and delivery research
The implementation of microfluidic devices within life sciences has furthered the possibilities
of both academic and industrial applications such as rapid genome sequencing, predictive …
of both academic and industrial applications such as rapid genome sequencing, predictive …
Comprehensive evaluation of organotypic and microphysiological liver models for prediction of drug-induced liver injury
Drug-induced liver injury (DILI) is a major concern for the pharmaceutical industry and
constitutes one of the most important reasons for the termination of promising drug …
constitutes one of the most important reasons for the termination of promising drug …
3D bioprinting of hepatocytes: Core–shell structured co-cultures with fibroblasts for enhanced functionality
With the aim of understanding and recapitulating cellular interactions of hepatocytes in their
physiological microenvironment and to generate an artificial 3D in vitro model, a co-culture …
physiological microenvironment and to generate an artificial 3D in vitro model, a co-culture …
3D bioprinting of bicellular liver lobule-mimetic structures via microextrusion of cellulose nanocrystal-incorporated shear-thinning bioink
Abstract 3D bioprinting of living cellular constructs with heterogeneity in cell types and extra
cellular matrices (ECMs) matching those of biological tissues remains challenging. Here, we …
cellular matrices (ECMs) matching those of biological tissues remains challenging. Here, we …
Core–shell bioprinting of vascularized in vitro liver sinusoid models
R Taymour, NA Chicaiza-Cabezas, M Gelinsky… - …, 2022 - iopscience.iop.org
In vitro liver models allow the investigation of the cell behavior in disease conditions or in
response to changes in the microenvironment. A major challenge in liver tissue engineering …
response to changes in the microenvironment. A major challenge in liver tissue engineering …
Comparison of conventional and advanced in vitro models in the toxicity testing of nanoparticles
E Fröhlich - Artificial cells, nanomedicine, and biotechnology, 2018 - Taylor & Francis
Humans are exposed to a wide variety of nanoparticles (NPs) present in the environment, in
consumer, health and medical products, and in food. Conventional cytotoxicity testing …
consumer, health and medical products, and in food. Conventional cytotoxicity testing …
Scaffold for liver tissue engineering: Exploring the potential of fibrin incorporated alginate dialdehyde–gelatin hydrogel
Introduction Development of a tissue-engineered construct for hepatic regeneration remains
a challenging task due to the lack of an optimum environment that support the growth of …
a challenging task due to the lack of an optimum environment that support the growth of …
[HTML][HTML] Complex intestinal and hepatic in vitro barrier models reveal information on uptake and impact of micro-, submicro-and nanoplastics
MB Paul, L Böhmert, IL Hsiao, A Braeuning… - Environment …, 2023 - Elsevier
Plastic particles are found almost ubiquitously in the environment and can get ingested
orally by humans. We have used food-relevant microplastics (2 µm polylactic acid) …
orally by humans. We have used food-relevant microplastics (2 µm polylactic acid) …
A pumpless liver-on-a-chip for drug hepatotoxicity analysis
D Jiao, L Xie, W Xing - Analyst, 2024 - pubs.rsc.org
This study presents the development and validation of an innovative microfluidic liver-on-a-
chip device utilizing gravity-driven perfusion for the evaluation of drug hepatotoxicity. This …
chip device utilizing gravity-driven perfusion for the evaluation of drug hepatotoxicity. This …
Current perspective: 3D spheroid models utilizing human-based cells for investigating metabolism-dependent drug-induced liver injury
CR Cox, S Lynch, C Goldring… - Frontiers in medical …, 2020 - frontiersin.org
Drug-induced liver injury (DILI) remains a leading cause for the withdrawal of approved
drugs. This has significant financial implications for pharmaceutical companies, places …
drugs. This has significant financial implications for pharmaceutical companies, places …