Conquering the hypoxia limitation for photodynamic therapy

Y Wan, LH Fu, C Li, J Lin, P Huang - Advanced Materials, 2021 - Wiley Online Library
Photodynamic therapy (PDT) has aroused great research interest in recent years owing to its
high spatiotemporal selectivity, minimal invasiveness, and low systemic toxicity. However …

Overcoming barriers in photodynamic therapy harnessing nano-formulation strategies

J Xie, Y Wang, W Choi, P Jangili, Y Ge, Y Xu… - Chemical Society …, 2021 - pubs.rsc.org
Photodynamic therapy (PDT) has been extensively investigated for decades for tumor
treatment because of its non-invasiveness, spatiotemporal selectivity, lower side-effects, and …

Engineering macrophage exosome disguised biodegradable nanoplatform for enhanced sonodynamic therapy of glioblastoma

T Wu, Y Liu, Y Cao, Z Liu - Advanced Materials, 2022 - Wiley Online Library
Sonodynamic therapy (SDT) exhibits high tissue penetration and negligible radiation
damage to normal tissues, and thus emerges as a promising cancer therapeutic modality for …

Biomimetic Nanozyme-Decorated Hydrogels with H2O2-Activated Oxygenation for Modulating Immune Microenvironment in Diabetic Wound

Y Zhao, D Wang, T Qian, J Zhang, Z Li, Q Gong… - ACS …, 2023 - ACS Publications
Diabetic foot ulcers (DFUs) remain a devastating threat to human health. While hydrogels
are promising systems for DFU-based wound management, their effectiveness is often …

Photodynamic therapy: Innovative approaches for antibacterial and anticancer treatments

M Kolarikova, B Hosikova, H Dilenko… - Medicinal Research …, 2023 - Wiley Online Library
Photodynamic therapy is an alternative treatment mainly for cancer but also for bacterial
infections. This treatment dates back to 1900 when a German medical school graduate …

Metal–organic framework derived nanozymes in biomedicine

D Wang, D Jana, Y Zhao - Accounts of chemical research, 2020 - ACS Publications
Conspectus Nanozymes, which integrate the advantages of both nanomaterials and natural
enzymes, have accumulated enormous research interest over the past decades because of …

An unexpected strategy to alleviate hypoxia limitation of photodynamic therapy by biotinylation of photosensitizers

J An, S Tang, G Hong, W Chen, M Chen, J Song… - Nature …, 2022 - nature.com
The most common working mechanism of photodynamic therapy is based on high-toxicity
singlet oxygen, which is called Type II photodynamic therapy. But it is highly dependent on …

Noncovalent Polymerization‐Activated Ultrastrong Near‐Infrared Room‐Temperature Phosphorescence Energy Transfer Assembly in Aqueous Solution

XY Dai, M Huo, X Dong, YY Hu, Y Liu - Advanced Materials, 2022 - Wiley Online Library
Noncovalent macrocycle‐confined supramolecular purely organic room‐temperature
phosphorescence (RTP) is a current research hotspot. Herein, a high‐efficiency noncovalent …

Gathering brings strength: How organic aggregates boost disease phototheranostics

J Qi, H Ou, Q Liu, D Ding - Aggregate, 2021 - Wiley Online Library
Phototheranostics that concurrently and complementarily integrate real‐time diagnosis and
in situ therapeutic capabilities in one platform has become the advancing edge of precision …

Emerging strategies in stimuli-responsive prodrug nanosystems for cancer therapy

C Ding, C Chen, X Zeng, H Chen, Y Zhao - ACS nano, 2022 - ACS Publications
Prodrugs are chemically modified drug molecules that are inactive before administration.
After administration, they are converted in situ to parent drugs and induce the mechanism of …