As the field of translational 'omics has progressed, refined classifiers at both genomic and
proteomic levels have emerged to decipher the heterogeneity of breast cancer in a clinically …

Intratumor heterogeneity has been widely reported in human cancers, but our knowledge of
how this genetic diversity emerges over time remains limited. A central challenge in studying …

We analysed whole-genome sequences of 560 breast cancers to advance understanding of
the driver mutations conferring clonal advantage and the mutational processes generating …

The mechanisms behind the evolution of complex genomic amplifications in cancer have
remained largely unclear. Using whole-genome sequencing data of the pediatric tumor …

Focal copy-number amplification is an oncogenic event. Although recent studies have
revealed the complex structure,–and the evolutionary trajectories of oncogene amplicons …

Aneuploidy is a hallmark of breast cancer; however, knowledge of how these complex
genomic rearrangements evolve during tumorigenesis is limited. In this study, we developed …

Sequencing studies of breast tumour cohorts have identified many prevalent mutations, but
provide limited insight into the genomic diversity within tumours. Here we developed a …

Breast carcinomas can be stratified into different entities based on clinical behavior,
histologic features, and/or by biological properties. A classification of breast cancer should …

Single-cell sequencing (SCS) is a powerful new tool for investigating evolution and diversity
in cancer and understanding the role of rare cells in tumor progression. These methods …

Genomic analysis provides insights into the role of copy number variation in disease, but
most methods are not designed to resolve mixed populations of cells. In tumours, where …