Knowledge of lipid droplets (LDs) has evolved from simple depots of lipid storage to
dynamic and functionally active organelles involved in a variety of cellular functions. Studies …

In the late 1990s, mutations in the synaptic protein α-synuclein (α-syn) were identified in
families with hereditary Parkinson's disease (PD). Rapidly, α-syn became the target of …

α-Synuclein (α-syn), particularly in its aggregated forms, is implicated in the pathogenesis of
Parkinson's disease and other related neurological disorders. However, the normal biology …

Aggregation of α‐synuclein, an abundant and conserved pre‐synaptic brain protein, is
implicated as a critical factor in several neurodegenerative diseases. These diseases …

Parkinson's disease (PD) progresses relentlessly and affects five million people worldwide.
Laboratory tests for PD are critically needed for developing treatments designed to slow or …

Among many achievements in the neurodegeneration field in the past decade, two require
special attention due to the huge impact on our understanding of molecular and cellular …

Genome-wide screens were performed in yeast to identify genes that enhance the toxicity of
a mutant huntingtin fragment or of α-synuclein. Of 4850 haploid mutants containing deletions …

Human neurodegenerative diseases are devastating illnesses that predominantly affect
elderly people. The majority of the diseases are associated with pathogenic oligomers from …

Neurodegenerative diseases are progressive disorders of the nervous system that affect
specific cellular populations in the central and peripheral nervous systems. Although most …

Background Previous studies have demonstrated reexpression of cell-cycle markers within
postmitotic neurons in neurodegenerative tauopathies, including Alzheimer's disease (AD) …