Regulation of microRNA function in animals

LFR Gebert, IJ MacRae - Nature reviews Molecular cell biology, 2019 - nature.com
Since their serendipitous discovery in nematodes, microRNAs (miRNAs) have emerged as
key regulators of biological processes in animals. These small RNAs form complex networks …

P-bodies: composition, properties, and functions

Y Luo, Z Na, SA Slavoff - Biochemistry, 2018 - ACS Publications
Processing bodies (P-bodies) are cytoplasmic ribonucleoprotein (RNP) granules primarily
composed of translationally repressed mRNAs and proteins related to mRNA decay …

Towards a molecular understanding of microRNA-mediated gene silencing

S Jonas, E Izaurralde - Nature reviews genetics, 2015 - nature.com
MicroRNAs (miRNAs) are a conserved class of small non-coding RNAs that assemble with
Argonaute proteins into miRNA-induced silencing complexes (miRISCs) to direct post …

Selective sorting of microRNAs into exosomes by phase-separated YBX1 condensates

XM Liu, L Ma, R Schekman - Elife, 2021 - elifesciences.org
Exosomes may mediate cell-to-cell communication by transporting various proteins and
nucleic acids to neighboring cells. Some protein and RNA cargoes are significantly enriched …

Clustered miRNAs and their role in biological functions and diseases

SP Kabekkodu, V Shukla, VK Varghese… - Biological …, 2018 - Wiley Online Library
MicroRNAs (miRNAs) are endogenous, small non‐coding RNAs known to regulate
expression of protein‐coding genes. A large proportion of miRNAs are highly conserved …

Therapeutic targeting of microRNAs: current status and future challenges

Z Li, TM Rana - Nature reviews Drug discovery, 2014 - nature.com
MicroRNAs (miRNAs) are evolutionarily conserved small non-coding RNAs that have crucial
roles in regulating gene expression. Increasing evidence supports a role for miRNAs in …

Argonaute proteins: functional insights and emerging roles

G Meister - Nature Reviews Genetics, 2013 - nature.com
Small-RNA-guided gene regulation has emerged as one of the fundamental principles in
cell function, and the major protein players in this process are members of the Argonaute …

The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC

MR Fabian, N Sonenberg - Nature structural & molecular biology, 2012 - nature.com
Since their discovery almost two decades ago, microRNAs (miRNAs) have been shown to
function by post-transcriptionally regulating protein accumulation. Understanding how …

Gene silencing by microRNAs: contributions of translational repression and mRNA decay

E Huntzinger, E Izaurralde - Nature Reviews Genetics, 2011 - nature.com
Despite their widespread roles as regulators of gene expression, important questions
remain about target regulation by microRNAs. Animal microRNAs were originally thought to …

MicroRNA: biogenesis, function and role in cancer

LA MacFarlane, PR Murphy - Current genomics, 2010 - ingentaconnect.com
MicroRNAs are small, highly conserved non-coding RNA molecules involved in the
regulation of gene expression. MicroRNAs are transcribed by RNA polymerases II and III …