Endosomes are central protein-sorting stations at the crossroads of numerous membrane
trafficking pathways in all eukaryotes. They have a key role in protein homeostasis and …

Abstract During endosomal recycling, Sorting Nexin 17 (SNX17) facilitates the transport of
numerous membrane cargo proteins by tethering them to the Retriever complex. Despite its …

Commander is a multiprotein complex that orchestrates endosomal recycling of integral
cargo proteins and is essential for normal development. While the structure of this complex …

Efficient induction of humoral immune responses depends on orchestrated migration of B
cells within lymphoid organs, which is governed by G protein-coupled receptors (GPCRs) …

Even though morphological signs of differentiation have a minimal impact on survival after
intensive cytotoxic therapy for acute myeloid leukemia (AML), monocytic AML cell …

The Retriever complex recycles a wide range of transmembrane proteins from endosomes
to the plasma membrane. The cargo adapter protein SNX17 has been implicated in …

Endosomal membrane trafficking is mediated by specific protein coats and formation of actin-
rich membrane domains. The Retromer complex coordinates with sorting nexin (SNX) cargo …

Early Endosomes sort transmembrane cargo whether for lysosomal degradation or retrieval
to the plasma membrane or the Golgi complex. Endosomal retrieval in eukaryotes is …

Background Mounting evidence shows that tumor-derived extracellular vesicles (EVs) are
critical constituents in the tumor microenvironment. The composition and function of EVs …

The emerging picture of G protein-coupled receptor function suggests that the global
signaling response is an integrated sum of a multitude of individual receptor responses …