Although the rate of acute severe adverse cutaneous reactions to medications is low, these
reactions can affect anyone who takes medications and can result in death or disability1 …

Since the first description by Saltzstein in 1959, the denomination of drug-induced
pseudolymphoma was used to describe two cutaneous adverse drug reactions with a …

Sulfonamides are the first successfully synthesized antimicrobial drugs. The mechanism of
sulfonamides antimicrobial action involves competitive inhibition of folic acid synthesis …

In their 60-year history, dapsone and the sulfones have been used as both antibacterial and
anti-inflammatory agents. Dapsone has been used successfully to treat a range of …

Drug-induced hepatotoxicity is a frequent cause of liver disease. Although often presenting
as acute hepatitis and/or cholestasis, virtually any clinicalpathological pattern of acute or …

OBJECTIVE: To perform a comprehensive review of Stevens-Johnson syndrome and toxic
epidermal necrolysis. DATA SOURCES: A MEDLINE search was performed for the years …

Idiosyncratic drug induced liver injury (DILI) remains poorly understood. It is assumed that
the affected individuals possess a rare combination of genetic and non genetic factors that, if …

Idiosyncratic drug reactions, sometimes referred to as hypersensitivity reactions or type B
reactions, are adverse drug reactions that do not occur in most patients at any dose and do …

Autoimmune hepatitis (AIH) is a disease of unknown cause with the following
characteristics:(1) it is associated with hypergammaglobulinemia;(2) is predominantly …

Cutaneous drug reactions are the most frequently occurring adverse reactions to drugs.
Among hospitalized patients, the incidence of these reactions ranges from 1 to 3%. The …