[HTML][HTML] Applications of artificial intelligence to aid early detection of dementia: a scoping review on current capabilities and future directions

R Li, X Wang, K Lawler, S Garg, Q Bai, J Alty - Journal of biomedical …, 2022 - Elsevier
Abstract Background & Objective With populations aging, the number of people with
dementia worldwide is expected to triple to 152 million by 2050. Seventy percent of cases …

Investigating the associations between upper limb motor function and cognitive impairment: a scoping review

KD Rudd, K Lawler, ML Callisaya, J Alty - GeroScience, 2023 - Springer
Upper limb motor function is a potential new biomarker of cognitive impairment and may aid
discrimination from healthy ageing. However, it remains unclear which assessments to use …

The TAS Test project: a prospective longitudinal validation of new online motor-cognitive tests to detect preclinical Alzheimer's disease and estimate 5-year risks of …

J Alty, Q Bai, R Li, K Lawler, RJ St George, E Hill… - BMC neurology, 2022 - Springer
Background The worldwide prevalence of dementia is rapidly rising. Alzheimer's disease
(AD), accounts for 70% of cases and has a 10–20-year preclinical period, when brain …

[HTML][HTML] Island study linking aging and neurodegenerative disease (ISLAND) targeting dementia risk reduction: protocol for a prospective web-based cohort study

L Bartlett, K Doherty, M Farrow, S Kim… - JMIR Research …, 2022 - researchprotocols.org
Background: Up to 40% of incident dementia is considered attributable to behavioral and
lifestyle factors. Given the current lack of medical treatments and the projected increase in …

Hand motor dysfunction is associated with both subjective and objective cognitive impairment across the dementia continuum

KD Rudd, K Lawler, ML Callisaya, J Alty - Dementia and Geriatric …, 2024 - karger.com
Introduction: Motor dysfunction is an important feature of early-stage dementia. Gait provides
a non-invasive biomarker across the dementia continuum. Gait speed and rhythm aid risk …

Estimating presymptomatic episodic memory impairment using simple hand movement tests: a cross‐sectional study of a large sample of older adults

X Wang, RJ St George, AD Bindoff… - Alzheimer's & …, 2024 - Wiley Online Library
INTRODUCTION Finding low‐cost methods to detect early‐stage Alzheimer's disease (AD)
is a research priority for neuroprotective drug development. Presymptomatic Alzheimer's is …

Linguistic, visuospatial, and kinematic writing characteristics in cognitively impaired patients with beta-amyloid deposition

SK An, H Jang, HJ Kim, DL Na… - Frontiers in Aging …, 2023 - frontiersin.org
Introduction Beta-amyloid (Aβ) deposition, a hallmark of Alzheimer's disease (AD), begins
before dementia and is an important factor in mild cognitive impairment (MCI). Aβ deposition …

Development of a smartphone screening test for preclinical Alzheimer's disease and validation across the dementia continuum

J Alty, LR Goldberg, E Roccati, K Lawler, Q Bai… - BMC neurology, 2024 - Springer
Background Dementia prevalence is predicted to triple to 152 million globally by 2050.
Alzheimer's disease (AD) constitutes 70% of cases. There is an urgent need to identify …

Brief webcam test of hand movements predicts episodic memory, executive function, and working memory in a community sample of cognitively asymptomatic older …

R Li, X Wang, K Lawler, S Garg… - Alzheimer's & …, 2024 - Wiley Online Library
INTRODUCTION Low‐cost simple tests for preclinical Alzheimer's disease are a research
priority. We evaluated whether remote unsupervised webcam recordings of finger‐tapping …

Smartphone automated motor and speech analysis for early detection of Alzheimer's disease and Parkinson's disease: Validation of TapTalk across 20 different …

R Li, G Huang, X Wang, K Lawler… - Alzheimer's & …, 2024 - Wiley Online Library
INTRODUCTION Smartphones are proving useful in assessing movement and speech
function in Alzheimer's disease and other neurodegenerative conditions. Valid outcomes …