Abstract Interleukin-12 (IL-12) and interleukin-23 (IL-23), which belong to the IL-12 family of
cytokines, have a key role in intestinal homeostasis and inflammation and are implicated in …

Abstract IL-12 and IL-23 are closely related cytokines with important roles in the regulation of
tissue inflammation. Converging evidence from studies in mice, human observational …

Genome-wide association studies have identified loci underlying human diseases, but the
causal nucleotide changes and mechanisms remain largely unknown. Here we developed a …

Abstract The cytokine interleukin-12 (IL-12) was thought to have a central role in T cell–
mediated responses in inflammation for more than a decade after it was first identified …

In this review, we provide an update on genome-wide association studies (GWAS) in
inflammatory bowel disease (IBD). In addition, we summarize progress in defining the …

Abstract The interleukin-23 [IL-23] cytokine, derived predominantly from macrophages and
dendritic cells in response to microbial stimulation, has emerged as a critical promoter of …

Objective Anti-tumour necrosis factor (TNF) antibodies are successfully used for treatment of
Crohn's disease. Nevertheless, approximately 40% of patients display failure to anti-TNF …

Inflammatory bowel disease is characterized by defects in epithelial function and
dysregulated inflammatory signaling by lamina propria mononuclear cells including …

Background We analysed incidence, predictors, histological features and specific treatment
options of anti-tumour necrosis factor α (TNF-α) antibody-induced psoriasiform skin lesions …

The skin provides the first line defense of the human body against injury and infection. By
integrating recent findings in cutaneous immunology with fundamental concepts of skin …