Exploring the amyloid degradation potential of nanoformulated carrageenan-bridging in vitro and in vivo perspectives

S Udayakumar, SK Metkar, A Girigoswami… - International Journal of …, 2024 - Elsevier
Amyloids, with their β-sheet-rich structure, contribute to diabetes, neurodegenerative
diseases, and amyloidosis by aggregating within diverse anatomical compartments. Insulin …

Polyisobutylenes with Controlled Molecular Weight and Chain-End Structure: Synthesis and Actual Applications

IE Nifant'ev, SA Korchagina, MS Chinova, AN Tavtorkin - Polymers, 2023 - mdpi.com
The polymerization of isobutylene allows us to obtain a wide spectrum of polyisobutylenes
(PIBs) which differ in their molecular weight characteristics and the chemical structure of …

From experimental studies to computational approaches: recent trends in designing novel therapeutics for amyloidogenesis

P Ghosh, A Kundu, D Ganguly - Journal of Materials Chemistry B, 2025 - pubs.rsc.org
Amyloidosis is a condition marked by misfolded proteins that build up in tissues and
eventually destroy organs. It has been connected to a number of fatal illnesses, including …

Crystallinity of side-chain fatty acid containing block copolymers with polyisobutylene segment

A Dey, S Mete, S Banerjee, U Haldar… - European Polymer …, 2023 - Elsevier
Block copolymers of polyisobutylene (PIB) with side-chain fatty acid-containing
polymethacrylate segment with varying n-alkyl side-chains were synthesized by the …

PIB-based block copolymer with a segment having alternating sequence of leucine and alanine side-chain pendants

A Dey, U Haldar, R Tota, R Faust… - Journal of Macromolecular …, 2023 - Taylor & Francis
A family of block copolymers with a hydrophobic polyisobutylene segment and another
segment with an alternating sequence of tert-butoxy carbonyl (Boc)-leucine containing …

Insulin fibril inhibition using glycopolymeric nanoassemblies

A Bera, P Ghosh, S Barman, S Bhattacharya… - Biomaterials …, 2023 - pubs.rsc.org
To address the obstacles in insulin protein homeostasis leading to the formation of
neurotoxic amyloid plaques associated with different diseases, herein we have synthesized …

Charge variable PIB-based block copolymers as selective transmembrane ion transporters

A Dey, U Haldar, T Rajasekhar, R Faust, P De - Polymer Chemistry, 2023 - pubs.rsc.org
Artificial functional ionophores are essential for selective transmembrane ion transport since
ion transport through biological membranes is an essential phenomenon and its disruption …

Biotinylated Theranostic Amphiphilic Polyurethane for Targeted Drug Delivery

S Bag, MP Gadpayle, D Ghosh, S Maiti… - Biomacromolecules, 2024 - ACS Publications
In the area of drug delivery aided by stimuli-responsive polymers, the biodegradability of
nanocarriers is one of the major challenges that needs to be addressed with the utmost …

Nanohybrid materials using gold nanoparticles and RAFT-synthesized polymers for biomedical applications

M Dhara - Journal of Macromolecular Science, Part A, 2023 - Taylor & Francis
Currently researchers are intensely exploring the potential of polymer coated inorganic
nanoparticles as materials of immense importance in context to theranostic applications, that …

Solvent effect on the self-assembly of polyisobutylene-based glycopolymers

A Dey, B Bhunia, MEH Khan, P De - Journal of Macromolecular …, 2024 - Taylor & Francis
Investigation of polymeric conformations in different solvents is critical because block
copolymer solution morphology is not only associated with the architecture but also with its …