The autophagy–NAD axis in longevity and disease
Autophagy is an intracellular degradation pathway that recycles subcellular components to
maintain metabolic homeostasis. NAD is an essential metabolite that participates in energy …
maintain metabolic homeostasis. NAD is an essential metabolite that participates in energy …
[HTML][HTML] Poly (ADP-Ribose) polymerase 1 and parthanatos in neurological diseases: From pathogenesis to therapeutic opportunities
X Xu, B Sun, C Zhao - Neurobiology of Disease, 2023 - Elsevier
Abstract Poly (ADP-ribose) polymerase-1 (PARP-1) is the most extensively studied member
of the PARP superfamily, with its primary function being the facilitation of DNA damage …
of the PARP superfamily, with its primary function being the facilitation of DNA damage …
Myeloid-derived MIF drives RIPK1-mediated cerebromicrovascular endothelial cell death to exacerbate ischemic brain injury
Y Li, C Zou, C Chen, S Li, Z Zhu… - Proceedings of the …, 2023 - National Acad Sciences
Macrophage migration inhibitory factor (MIF) is a multifaced protein that plays important
roles in multiple inflammatory conditions. However, the role of MIF in endothelial cell (EC) …
roles in multiple inflammatory conditions. However, the role of MIF in endothelial cell (EC) …
Disulfiram blocks inflammatory TLR4 signaling by targeting MD-2
Y Bai, R Min, P Chen, S Mei, F Deng… - Proceedings of the …, 2023 - National Acad Sciences
Toll-like receptor 4 (TLR4) sensing of lipopolysaccharide (LPS), the most potent pathogen-
associated molecular pattern of gram-negative bacteria, activates NF-κB and Irf3, which …
associated molecular pattern of gram-negative bacteria, activates NF-κB and Irf3, which …
Upregulation of Ca2+-binding proteins contributes to VTA dopamine neuron survival in the early phases of Alzheimer's disease in Tg2576 mice
L La Barbera, A Nobili, E Cauzzi, I Paoletti… - Molecular …, 2022 - Springer
Background Recent clinical and experimental studies have highlighted the involvement of
Ventral Tegmental Area (VTA) dopamine (DA) neurons for the early pathogenesis of …
Ventral Tegmental Area (VTA) dopamine (DA) neurons for the early pathogenesis of …
α-Synuclein pathology as a target in neurodegenerative diseases
Abstract α-Synuclein misfolds into pathological forms that lead to various neurodegenerative
diseases known collectively as α-synucleinopathies. In this Review, we provide a …
diseases known collectively as α-synucleinopathies. In this Review, we provide a …
Poly (ADP-ribose) polymerase 1 and neurodegenerative diseases: Past, present, and future
ML Hu, YR Pan, YY Yong, Y Liu, L Yu, DL Qin… - Ageing research …, 2023 - Elsevier
Abstract Poly (ADP-ribose) polymerase 1 (PARP1) is a first responder that recognizes DNA
damage and facilitates its repair. Neurodegenerative diseases, characterized by progressive …
damage and facilitates its repair. Neurodegenerative diseases, characterized by progressive …
Targeting modulation of intestinal flora through oral route by an antimicrobial nucleic acid-loaded exosome-like nanovesicles to improve Parkinson's disease
W Cui, Z Guo, X Chen, R Yan, W Ma, X Yang, Y Lin - Science Bulletin, 2024 - Elsevier
Parkinson's disease (PD) is one of the most prevalent neurodegenerative diseases. It is
usually accompanied by motor and non-motor symptoms that seriously threaten the health …
usually accompanied by motor and non-motor symptoms that seriously threaten the health …
The biphasic role of Hspb1 on ferroptotic cell death in Parkinson's disease
J Meng, J Fang, Y Bao, H Chen, X Hu, Z Wang… - …, 2024 - pmc.ncbi.nlm.nih.gov
Rationale: Ferroptosis-driven loss of dopaminergic neurons plays a pivotal role in the
pathogenesis of Parkinson's disease (PD). In PD patients, Hspb1 is commonly observed at …
pathogenesis of Parkinson's disease (PD). In PD patients, Hspb1 is commonly observed at …
Blocking the Self‐Destruct Program of Dopamine Neurons through Macrophage Migration Inhibitory Factor Nuclease Inhibition
Parkinson's disease (PD) is a progressive neurodegenerative condition that
pathognomonically involves the death of dopaminergic neurons in the substantia nigra pars …
pathognomonically involves the death of dopaminergic neurons in the substantia nigra pars …