Dynamic alternative DNA structures in biology and disease
G Wang, KM Vasquez - Nature Reviews Genetics, 2023 - nature.com
Repetitive elements in the human genome, once considered 'junk DNA', are now known to
adopt more than a dozen alternative (that is, non-B) DNA structures, such as self-annealed …
adopt more than a dozen alternative (that is, non-B) DNA structures, such as self-annealed …
G-quadruplex DNA: a novel target for drug design
FY Teng, ZZ Jiang, M Guo, XZ Tan, F Chen… - Cellular and Molecular …, 2021 - Springer
Abstract G-quadruplex (G4) DNA is a type of quadruple helix structure formed by a
continuous guanine-rich DNA sequence. Emerging evidence in recent years authenticated …
continuous guanine-rich DNA sequence. Emerging evidence in recent years authenticated …
G-quadruplex structures in bacteria: biological relevance and potential as an antimicrobial target
ABSTRACT DNA strands consisting of multiple runs of guanines can adopt a noncanonical,
four-stranded DNA secondary structure known as G-quadruplex or G4 DNA. G4 DNA is …
four-stranded DNA secondary structure known as G-quadruplex or G4 DNA. G4 DNA is …
A helicase unwinds hexanucleotide repeat RNA G-quadruplexes and facilitates repeat-associated non-AUG translation
The expansion of a hexanucleotide repeat GGGGCC (G4C2) in the C9orf72 gene is the
most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia …
most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia …
Genomic Instability of G-Quadruplex Sequences in Escherichia coli: Roles of DinG, RecG, and RecQ Helicases
Guanine-rich DNA can fold into highly stable four-stranded DNA structures called G-
quadruplexes (G4). Originally identified in sequences from telomeres and oncogene …
quadruplexes (G4). Originally identified in sequences from telomeres and oncogene …
G-quadruplexes in bacteria: insights into the regulatory roles and interacting proteins of non-canonical nucleic acid structures
Abstract G-quadruplexes (G4s) are highly stable, non-canonical DNA or RNA structures that
can form in guanine-rich stretches of nucleic acids. G4-forming sequences have been found …
can form in guanine-rich stretches of nucleic acids. G4-forming sequences have been found …
Vectorial folding of telomere overhang promotes higher accessibility
Human telomere overhang composed of tandem repeats of TTAGGG folds into G-
quadruplex (G4). Unlike in an experimental setting in the test tube in which the entire length …
quadruplex (G4). Unlike in an experimental setting in the test tube in which the entire length …
Regeneration of PEG slide for multiple rounds of single-molecule measurements
Single-molecule fluorescence detection of protein and other biomolecules requires a
polyethylene glycol (PEG)-passivated surface. Individual channels on a PEG-passivated …
polyethylene glycol (PEG)-passivated surface. Individual channels on a PEG-passivated …
Essential roles and risks of G-quadruplex regulation: recognition targets of ALS-linked TDP-43 and FUS
A Ishiguro, A Ishihama - Frontiers in Molecular Biosciences, 2022 - frontiersin.org
A non-canonical DNA/RNA structure, G-quadruplex (G4), is a unique structure formed by two
or more guanine quartets, which associate through Hoogsteen hydrogen bonding leading to …
or more guanine quartets, which associate through Hoogsteen hydrogen bonding leading to …
[HTML][HTML] Protocol for generation and regeneration of PEG-passivated slides for single-molecule measurements
Single-molecule fluorescence detection by total internal reflection microscope requires
surface passivation by polyethylene glycol (PEG) coating, which is labor intensive and is …
surface passivation by polyethylene glycol (PEG) coating, which is labor intensive and is …