Glucokinase is a key regulatory enzyme in the pancreatic beta‐cell. It plays a crucial role in
the regulation of insulin secretion and has been termed the glucose sensor in pancreatic …

Monogenic diabetes resulting from mutations that primarily reduce β-cell function accounts
for 1–2% of diabetes cases, although it is often misdiagnosed as either type 1 or type 2 …

Monogenic diabetes results from one or more defects in a single gene. The disease may be
inherited within families as a dominant, recessive or non-Mendelian trait or may present as a …

ISPAD Clinical Practice Consensus Guidelines 2022: The diagnosis and management of
monogenic diabetes in children and adolescents - PMC Back to Top Skip to main content NIH …

The aim of this paper is to review the information on type 1 and type 2 diabetes with
emphasis on its etiology, pathogenesis and pathophysiology via literature review. Diabetes …

Background Patients with permanent neonatal diabetes usually present within the first three
months of life and require insulin treatment. In most, the cause is unknown. Because ATP …

The glucokinase (GCK) gene was one of the first candidate genes to be identified as a
human “diabetes gene". Subsequently, important advances were made in understanding the …

Glucokinase, a unique isoform of the hexokinase enzymes, which are known to
phosphorylate d-glucose and other hexoses, was identified during the past three to four …

Monogenic diabetes results from one or more defects in a single gene. The disease may be
inherited within families as a dominant, recessive, or non-Mendelian trait or may present as …

Individuals with permanent neonatal diabetes mellitus usually present within the first three
months of life and require insulin treatment,. We recently identified a locus on chromosome …