Lysosomal storage disorders (LSDs) are a group of monogenic diseases characterized by
progressive accumulation of undegraded substrates into the lysosome, due to mutations in …

Lysosomal acid lipase and lipid metabolism: new mechanisms,... : Current Opinion in
Lipidology Lysosomal acid lipase and lipid metabolism: new mechanisms, new questions, and …

Allele-specific expression (ASE) analysis, which quantifies the relative expression of two
alleles in a diploid individual, is a powerful tool for identifying cis-regulated gene expression …

Objective: We previously reported smooth muscle cells (SMCs) represent≥ 50% of foam
cells in human coronary and≈ 70% in apoE (apolipoprotein E)-deficient mouse aortic …

CRISPR–Cas9 genome editing technology is a promising tool for genetically engineering
immune cells and modulating immune systems. Although ex vivo genome editing of immune …

Macrophages (Mφ) derived from induced pluripotent stem cells (iMphs) represent a novel
and promising model for studying human Mφ function and differentiation and developing …

Genome engineering using CRISPR/Cas9 technology enables simple, efficient and precise
genomic modifications in human cells. Conventional immortalized cell lines can be easily …

Rapid advancement in genome editing technologies has provided new promises for treating
neoplasia, cardiovascular, neurodegenerative, and monogenic disorders. Recently, the …

The generation of human macrophages from induced pluripotent stem cells (iMacs) is a
rapidly developing approach used to create disease models, screen drugs, study …

The CRISPR-Cas9 genome editing tool is used to study genomic variants and gene
knockouts, and can be combined with transcriptomic analyses to measure the effects of such …