In the immature brain, GABA (γ-aminobutyric acid) is excitatory, and GABA-releasing
synapses are formed before glutamatergic contacts in a wide range of species and …

Neurobiologists have long sought to understand how circuits in the nervous system are
organized to generate the precise neural outputs that underlie particular behaviours. The …

This book reviews research on the development of brain and behaviour in the chick. It
begins by outlining the developmental stages of the chick embryo, including the effects of …

We examined the ability of the isolated lumbosacral spinal cord of the neonatal mouse (P0–
7) to generate rhythmic motor activity under several different conditions. In the absence of …

In the developing nervous system, patterned spontaneous activity affects a variety of
developmental processes. Thus, it is important to identify the earliest time that such activity …

Motivated by the challenge of improving neuroprosthetic devices, the authors review current
knowledge relating to harnessing the potential of spinal neural circuits, such as reflexes and …

Motoneurones are known to die (1) during embryonic development (naturally occurring cell
death),(2) early in postnatal development after axonal injury, and (3) as a consequence of …

The influence of polysialic acid (PSA) on the neural cell adhesion molecule on motoneuron
outgrowth and pathway formation was investigated by determining its temporal and spatial …

Spontaneous episodic activity is a general feature of developing neural networks. In the
chick spinal cord, the activity comprises episodes of rhythmic discharge (duration 5–90 sec; …

Patterned spontaneous electrical activity has been demonstrated in a number of developing
neural circuits and has been proposed to play a role in refining connectivity once axons …