Cytokines are major regulators of innate and adaptive immunity that enable cells of the
immune system to communicate over short distances. Cytokine therapy to activate the …

In the early nineties, pioneering steps were taken in the use of mRNA as a therapeutic tool
for vaccination. In the following decades, an improved understanding of the mRNA …

Local immunotherapy ideally stimulates immune responses against tumors while avoiding
toxicities associated with systemic administration. Current strategies for tumor-targeted …

Type I interferons (IFNs) are known for their key role in antiviral immune responses. In this
Review, we discuss accumulating evidence indicating that type I IFNs produced by …

Abstract Antibody‒drug conjugates (ADCs), which combine the advantages of monoclonal
antibodies with precise targeting and payloads with efficient killing, show great clinical …

Poly (ADP-ribose) polymerase (PARP) superfamily members covalently link either a single
ADP-ribose (ADPR) or a chain of ADPR units to proteins using NAD as the source of ADPR …

The toxicities of immunotherapy for cancer are as diverse as the type of treatments that have
been devised. These range from cytokine therapies that induce capillary leakage to …

Cytokines are molecular messengers that allow the cells of the immune system to
communicate with one another to generate a coordinated, robust, but self-limited response …

Abstract Interferon-γ (IFN-γ) coordinates a diverse array of cellular programs through
transcriptional regulation of immunologically relevant genes. This article reviews the current …

Keloids are abnormal scars that cause significant emotional and physical distress in patients
when inadequately treated. Keloid formation is theorized to occur as a result of an …