Emergence of SARS-CoV-2 Omicron (B. 1.1. 529) variant, salient features, high global health concerns and strategies to counter it amid ongoing COVID-19 pandemic

R Khandia, S Singhal, T Alqahtani, MA Kamal… - Environmental …, 2022 - Elsevier
Since the appearance in the late of December 2019, SARS-CoV-2 is rapidly evolving and
mutating continuously, giving rise to various variants with variable degrees of infectivity and …

The outbreak of SARS‐CoV‐2 Omicron lineages, immune escape, and vaccine effectivity

Y Zhou, H Zhi, Y Teng - Journal of medical virology, 2023 - Wiley Online Library
As of November 2021, several SARS‐CoV‐2 variants appeared and became dominant
epidemic strains in many countries, including five variants of concern (VOCs) Alpha, Beta …

Pan-peptide meta learning for T-cell receptor–antigen binding recognition

Y Gao, Y Gao, Y Fan, C Zhu, Z Wei, C Zhou… - Nature Machine …, 2023 - nature.com
The identification of the mechanisms by which T-cell receptors (TCRs) interact with human
antigens provides a crucial opportunity to develop new vaccines, diagnostics and …

SARS-CoV-2: a master of immune evasion

A Rubio-Casillas, EM Redwan, VN Uversky - Biomedicines, 2022 - mdpi.com
Viruses and their hosts have coevolved for a long time. This coevolution places both the
pathogen and the human immune system under selective pressure; on the one hand, the …

[HTML][HTML] A comprehensive review on Covid-19 Omicron (B. 1.1. 529) variant

R Manjunath, SL Gaonkar, EAM Saleh… - Saudi journal of biological …, 2022 - Elsevier
The world has been combating different variants of SARS-COV-19 since its first outbreak in
Wuhan city. SARS-COV-19 is caused by the coronavirus. The corona virus mutates and …

[HTML][HTML] Longitudinal analysis of T cell receptor repertoires reveals shared patterns of antigen-specific response to SARS-CoV-2 infection

RM Gittelman, E Lavezzo, TM Snyder, HJ Zahid… - JCI insight, 2022 - ncbi.nlm.nih.gov
T cells play a prominent role in orchestrating the immune response to viral diseases, but
their role in the clinical presentation and subsequent immunity to SARS-CoV-2 infection …

T‐cell responses to SARS‐CoV‐2 Omicron spike epitopes with mutations after the third booster dose of an inactivated vaccine

Y Li, X Wang, J Jin, Z Ma, Y Liu… - Journal of medical …, 2022 - Wiley Online Library
The rapidly spreading severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)
Omicron variant contains more than 30 mutations that mediate escape from antibody …

Alterations in SARS-CoV-2 Omicron and Delta peptides presentation by HLA molecules

S Nersisyan, A Zhiyanov, M Zakharova, I Ishina… - PeerJ, 2022 - peerj.com
The T-cell immune response is a major determinant of effective SARS-CoV-2 clearance.
Here, using the recently developed T-CoV bioinformatics pipeline (https://t-cov. hse. ru) we …

Omicron variant infection and the associated immunological scenario

AG Mukherjee, UR Wanjari, R Murali, U Chaudhary… - Immunobiology, 2022 - Elsevier
The million-dollar question that has been the talk of the day is how effective the COVID 19
vaccines are against the Omicron variant. Still, there is no clear-cut answer to this question …

Defining the determinants of protection against SARS-CoV-2 infection and viral control in a dose-down Ad26. CoV2. S vaccine study in nonhuman primates

DY Zhu, MJ Gorman, D Yuan, J Yu, NB Mercado… - PLoS …, 2022 - journals.plos.org
Despite the rapid creation of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-
CoV-2) vaccines, the precise correlates of immunity against severe Coronavirus Disease …