Bioactivity of natural biflavonoids in metabolism-related disease and cancer therapies

JC Menezes, MF Diederich - Pharmacological research, 2021 - Elsevier
Natural biflavonoids, such as amentoflavone, bilobetin, ginkgetin, isoginkgetin,
taiwaniaflavone, morelloflavone, delicaflavone, hinokiflavone, and other derivatives (~ 40 …

Medicinal plants and phytochemicals against multidrug-resistant tumor cells expressing ABCB1, ABCG2, or ABCB5: a synopsis of 2 decades

T Efferth, O Kadioglu, MEM Saeed, EJ Seo… - Phytochemistry …, 2021 - Springer
Multidrug resistance is a major factor causing the failure of cancer chemotherapy. Efflux
pumps of the ATP-binding cassette (ABC) transporter family expel a large array of diverse …

Cytotoxicity of the methanol extracts and compounds of Brucea antidysenterica (Simaroubaceae) towards multifactorial drug-resistant human cancer cell lines

LM Youmbi, YSD Makong, AT Mbaveng… - … Medicine and Therapies, 2023 - Springer
Background Cancer remains a global health concern and constitutes an important barrier to
increasing life expectancy. Malignant cells rapidly develop drug resistance leading to many …

Identification of a new natural biflavonoids against breast cancer cells induced ferroptosis via the mitochondrial pathway

Y Xie, X Zhou, J Li, XC Yao, WL Liu, FH Kang… - Bioorganic …, 2021 - Elsevier
Breast cancer is one of the major malignant tumors in females, and currently, recurrence and
metastasis are the main obstacles preventing effective breast cancer treatment. Biflavonoids …

Cytotoxic phytochemicals from the crude extract of Tetrapleura tetraptera fruits towards multi-factorial drug resistant cancer cells

AT Mbaveng, GF Chi, IN Bonsou, JO Ombito… - Journal of …, 2021 - Elsevier
Ethnopharmacological relevance Tetrapleura tetraptera is an African medicinal spice used
in traditional medicine to treat several ailments including cancer. Aim of the study The …

N-acetylglycoside of oleanolic acid (aridanin) displays promising cytotoxicity towards human and animal cancer cells, inducing apoptotic, ferroptotic and necroptotic …

AT Mbaveng, GF Chi, IN Bonsou, S Abdelfatah… - Phytomedicine, 2020 - Elsevier
Background The discovery of novel phytochemicals represents a reasonable approach to
fight malignancies, especially those which are resistant to standard chemotherapy. Purpose …

Ethnopharmacology, phytochemistry and pharmacology of potent antibacterial medicinal plants from Africa

V Kuete - Advances in Botanical Research, 2023 - Elsevier
In this chapter, the traditional use, the phytochemical composition, and the pharmacological
activities of African medicinal plants displaying antibacterial effects were reported. We have …

Proceedings of chemistry, pharmacology, pharmacokinetics and synthesis of biflavonoids

X He, F Yang, X Huang - Molecules, 2021 - mdpi.com
Biflavonoids, composed of two monoflavonoid residues, occur naturally in angiosperms,
bryophytes, ferns, and gymnosperms. More than 592 biflavonoids have been structurally …

Targeting cancer metabolism to resensitize chemotherapy: potential development of cancer chemosensitizers from traditional Chinese medicines

W Guo, HY Tan, F Chen, N Wang, Y Feng - Cancers, 2020 - mdpi.com
Cancer is a common and complex disease with high incidence and mortality rates, which
causes a severe public health problem worldwide. As one of the standard therapeutic …

Induction of Apoptosis, Autophagy and Ferroptosis by Thymus vulgaris and Arctium lappa Extract in Leukemia and Multiple Myeloma Cell Lines

A N. Adham, ME F. Hegazy, AM Naqishbandi, T Efferth - Molecules, 2020 - mdpi.com
Thymus vulgaris and Arctium lappa have been used as a folk remedy in the Iraqi Kurdistan
region to deal with different health problems. The aim of the current study is to investigate …