The hypotheses on the pathophysiology of depression/mood disorders and on
antidepressant mechanisms have greatly changed in recent years. The classical …

Brain-derived neurotrophic factor (BDNF) has a crucial function in the central nervous
system and in sensory structures including olfactory and auditory systems. Many studies …

Abstract The sigma‐1 receptor (Sig‐1R) is a novel endoplasmic reticulum (ER) molecular
chaperone that regulates protein folding and degradation. The Sig‐1R activation by agonists …

Abstract Background Gelsemium sempervirens L.(Gelsemium s.) is a traditional medicinal
plant, employed as an anxiolytic at ultra-low doses and animal models recently confirmed …

The aim of the study is to compare the expression level of candidate genes between patients
suffering from a severe major depressive episode (MDE) and controls, and also among …

Background The neurotrophin BDNF has been implicated in the regulation of
neuroplasticity, gene expression, and synaptic function in the adult brain, as well as in the …

Ethnopharmacological relevance Gelsemium sempervirens L. is a traditional medicinal plant
mainly distributed in the southeastern of the United States, employed in phytotheraphy and …

The molecular pathways involved in methylmercury (MeHg)-induced neurotoxicity are not
fully understood. Since pan-Histone deacetylases (HDACs) inhibition has been found to …

Several noncoding microRNAs (miR or miRNA) have been shown to regulate the
expression of drug‐metabolizing enzymes and transporters. Xenobiotic drug‐induced …

Sexual dysfunction is not only a common symptom in major depression but also a frequent
side-effect of antidepressant medication, mainly of the selective serotonin reuptake …