Gut microbiota in colorectal cancer development and therapy

CC Wong, J Yu - Nature Reviews Clinical Oncology, 2023 - nature.com
Colorectal cancer (CRC) is one of the commonest cancers globally. A unique aspect of CRC
is its intimate association with the gut microbiota, which forms an essential part of the tumour …

[HTML][HTML] Microbiome and cancer

N Cullin, CA Antunes, R Straussman… - Cancer Cell, 2021 - cell.com
The human microbiome constitutes a complex multikingdom community that symbiotically
interacts with the host across multiple body sites. Host-microbiome interactions impact …

A pan-cancer mycobiome analysis reveals fungal involvement in gastrointestinal and lung tumors

AB Dohlman, J Klug, M Mesko, IH Gao, SM Lipkin… - Cell, 2022 - cell.com
Fungal microorganisms (mycobiota) comprise a small but immunoreactive component of the
human microbiome, yet little is known about their role in human cancers. Pan-cancer …

[HTML][HTML] High-fat diet promotes colorectal tumorigenesis through modulating gut microbiota and metabolites

J Yang, H Wei, Y Zhou, CH Szeto, C Li, Y Lin… - Gastroenterology, 2022 - Elsevier
Background and Aims Dietary fat intake is associated with increased risk of colorectal
cancer (CRC). We examined the role of high-fat diet (HFD) in driving CRC through …

Inflammation: the incubator of the tumor microenvironment

D Denk, FR Greten - Trends in Cancer, 2022 - cell.com
An inflammatory microenvironment, either conferred by an underlying chronic overt or
smoldering inflammatory condition constitutes a prerequisite and fuel to essentially all …

The intestinal microbiota and colorectal cancer

Y Cheng, Z Ling, L Li - Frontiers in immunology, 2020 - frontiersin.org
The intestinal microbiota, composed of a large population of microorganisms, is often
considered a “forgotten organ” in human health and diseases. Increasing evidence indicates …

Fusobacterium nucleatum, a key pathogenic factor and microbial biomarker for colorectal cancer

N Wang, JY Fang - Trends in Microbiology, 2023 - cell.com
Colorectal cancer (CRC), one of the most prevalent cancers, has complex etiology. The
dysbiosis of intestinal bacteria has been highlighted as an important contributor to CRC …

Multi-kingdom microbiota analyses identify bacterial–fungal interactions and biomarkers of colorectal cancer across cohorts

NN Liu, N Jiao, JC Tan, Z Wang, D Wu, AJ Wang… - Nature …, 2022 - nature.com
Despite recent progress in our understanding of the association between the gut
microbiome and colorectal cancer (CRC), multi-kingdom gut microbiome dysbiosis in CRC …

Host–microbiota maladaptation in colorectal cancer

A Janney, F Powrie, EH Mann - Nature, 2020 - nature.com
Colorectal cancer (CRC) is a heterogeneous disease of the intestinal epithelium that is
characterized by the accumulation of mutations and a dysregulated immune response. Up to …

Global burden of colorectal cancer: emerging trends, risk factors and prevention strategies

NN Keum, E Giovannucci - Nature reviews Gastroenterology & …, 2019 - nature.com
Globally, colorectal cancer (CRC) is the third most commonly diagnosed malignancy and the
second leading cause of cancer death. Arising through three major pathways, including …