Cancer progression with uncontrolled tumor growth, local invasion, and metastasis depends
largely on the proteolytic activity of numerous matrix metalloproteinases (MMPs), which …

The extracellular matrix (ECM) constitutes the scaffold of tissues and organs. It is a complex
network of extracellular proteins, proteoglycans and glycoproteins, which form …

Integrins are heterodimeric cell surface receptors ensuring the mechanical connection
between cells and the extracellular matrix. In addition to the anchorage of cells to the …

In contrast to solid cancers, which often require genetic modifications and complex cellular
reprogramming for effective metastatic dissemination, leukaemic cells uniquely possess the …

Multicellular cancer spheroids (MCSs) have emerged as a promising in vitro model that
replicates many features of solid tumors in vivo. Biomimetic hydrogel scaffolds for MCS …

In epithelial cancers, cells must invade through basement membranes (BMs) to metastasize.
The BM, a thin layer of extracellular matrix underlying epithelial and endothelial tissues, is …

Membrane-type matrix metalloproteinases (MT-MMPs) form a subgroup of the matrix
metalloproteinase (MMP) family, and there are 6 MT-MMPs in humans. MT-MMPs are further …

Cell migration affects all morphogenetic processes and contributes to numerous diseases,
including cancer and cardiovascular disease. For most cells in most environments …

Podosomes and invadopodia are actin-based dynamic protrusions of the plasma membrane
of metazoan cells that represent sites of attachment to—and degradation of—the …

Cell migration requires sustained forward movement of the plasma membrane at the cell's
front or" leading edge." To date, researchers have uncovered four distinct ways of extending …