Targeting RNAs with small molecules represents a new frontier in drug discovery and
development. The rich structural diversity of folded RNAs offers a nearly unlimited reservoir …

Like all retroviruses, the human immunodeficiency virus selectively packages two copies of
its unspliced RNA genome, both of which are utilized for strand-transfer-mediated …

Highly conserved noncoding RNA (ncRNA) elements in viral genomes and transcripts offer
new opportunities to expand the repertoire of drug targets for the development of …

Background: Thiazole is a good nucleus owing to its various pharmaceutical applications.
Thiazole containing compounds (thiazoles) have shown various biological activities like …

MicroRNAs (miRNAs) are a recently discovered category of small RNA molecules that
regulate gene expression at the post-transcriptional level. Accumulating evidence indicates …

The use of purified and overexpressed alcohol dehydrogenases to synthesize enantiopure
fluorinated alcohols is shown. When the bioreductions were performed with ADH-A from …

A simple and efficient synthesis of modified 1, 2, 3-triazole nucleosides was developed. The
strategy involved sequential one-pot acetylation-azidation-cycloaddition procedure and was …

Identifying small molecules that selectively bind an RNA target while discriminating against
all other cellular RNAs is an important challenge in RNA-targeted drug discovery. Much …

MicroRNAs (miRNAs) are a recently discovered category of small RNA molecules that
regulate gene expression at the post-transcriptional level. Accumulating evidence indicates …

Despite the use of highly active antiretroviral therapy approved by the United States Food
and Drug Administration (FDA) for the treatment of human immunodeficiency virus (HIV) …