Context-specific regulation of extracellular vesicle biogenesis and cargo selection

AC Dixson, TR Dawson, D Di Vizio… - … Reviews Molecular Cell …, 2023 - nature.com
To coordinate, adapt and respond to biological signals, cells convey specific messages to
other cells. An important aspect of cell–cell communication involves secretion of molecules …

Exosome biogenesis: machinery, regulation, and therapeutic implications in cancer

QF Han, WJ Li, KS Hu, J Gao, WL Zhai, JH Yang… - Molecular cancer, 2022 - Springer
Exosomes are well-known key mediators of intercellular communication and contribute to
various physiological and pathological processes. Their biogenesis involves four key steps …

The ins-and-outs of exosome biogenesis, secretion, and internalization

SB Arya, SP Collie, CA Parent - Trends in cell biology, 2024 - cell.com
Exosomes are specialized cargo delivery vesicles secreted from cells by fusion of
multivesicular bodies (MVBs) with the plasma membrane (PM). While the function of …

The machinery of exosomes: biogenesis, release, and uptake

SV Krylova, D Feng - International Journal of Molecular Sciences, 2023 - mdpi.com
Exosomes are a subtype of membrane-contained vesicles 40–200 nm in diameter that are
secreted by cells into their surroundings. By transporting proteins, lipids, mRNA, miRNA …

Exosomes as mediators of intercellular crosstalk in metabolism

R Isaac, FCG Reis, W Ying, JM Olefsky - Cell metabolism, 2021 - cell.com
Exosomes are nanoparticles secreted by all cell types and are a large component of the
broader class of nanoparticles termed extracellular vesicles (EVs). Once secreted …

The exosome journey: from biogenesis to uptake and intracellular signalling

S Gurung, D Perocheau, L Touramanidou… - Cell Communication and …, 2021 - Springer
The use of exosomes in clinical settings is progressively becoming a reality, as clinical trials
testing exosomes for diagnostic and therapeutic applications are generating remarkable …

The updated role of exosomal proteins in the diagnosis, prognosis, and treatment of cancer

X Wang, J Huang, W Chen, G Li, Z Li… - Experimental & molecular …, 2022 - nature.com
Exosomes are vesicles encompassed by a lipid bilayer that are released by various living
cells. Exosomal proteins are encapsulated within the membrane or embedded on the …

Exploiting the biogenesis of extracellular vesicles for bioengineering and therapeutic cargo loading

J Rädler, D Gupta, A Zickler, SEL Andaloussi - Molecular Therapy, 2023 - cell.com
Extracellular vesicles (EVs) are gaining increasing attention for diagnostic and therapeutic
applications in various diseases. These natural nanoparticles benefit from favorable safety …

Shedding light on extracellular vesicle biogenesis and bioengineering

F Teng, M Fussenegger - Advanced Science, 2021 - Wiley Online Library
Extracellular vesicles (EVs) are biocompatible, nano‐sized secreted vesicles containing
many types of biomolecules, including proteins, RNAs, DNAs, lipids, and metabolites. Their …

FSP1: a key regulator of ferroptosis

W Li, L Liang, S Liu, H Yi, Y Zhou - Trends in Molecular Medicine, 2023 - cell.com
Abstract Ferroptosis suppressor protein 1 (FSP1) is one of the main regulatory molecules of
ferroptosis. FSP1 functions through the FSP1-coenzyme Q10 (CoQ10)-NAD (P) H axis and …