Inwardly rectifying K+ (Kir) channels allow K+ to move more easily into rather than out of the
cell. They have diverse physiological functions depending on their type and their location …

KATP channels are integral to the functions of many cells and tissues. The use of
electrophysiological methods has allowed for a detailed characterization of KATP channels …

ATP-sensitive potassium (KATP) channels, so named because they are inhibited by
intracellular ATP, play key physiological roles in many tissues. In pancreatic β cells, these …

Potassium channels are particularly important in determining the shape and duration of the
action potential, controlling the membrane potential, modulating hormone secretion …

Twenty years after the discovery of sarcolemmal ATP-sensitive K+ channels and 12 years
after the discovery of mitochondrial KATP (mitoKATP) channels, progress has been …

A prolonged period of ischaemia followed by reperfusion irreversibly damages the heart.
Such reperfusion injury (RI) involves opening of the mitochondrial permeability transition …

ATP sensitive potassium channels (KATP) are so named because they open as cellular ATP
levels fall. This leads to membrane hyperpolarization and thus links cellular metabolism to …

In work spanning more than a century, mitochondria have been recognized for their
multifunctional roles in metabolism, energy transduction, ion transport, inheritance …

Adenosine triphosphate (ATP)-binding cassette (ABC) transporters may play an important
role in the pathogenesis of atherosclerotic vascular diseases due to their involvement in …

Preconditioning by one or several brief periods of ischemia activates an endogenous
cardioprotective program that increases the resistance of cardiomyocytes to injury by …