The elevated plus-maze test has been in use as a rodent model of anxiety for a decade, and
is representative of those tests that are based upon the study of spontaneous behaviour …

As well as being considered a reliable measurement instrument of animal anxiety-like
behavior, the elevated plus-maze (EPM) is also used as a post-hoc test to evaluate …

A model of the neuropsychology of anxiety is proposed. The model is based in the first
instance upon an analysis of the behavioural effects of the antianxiety drugs …

The elevated plus maze is a widely used behavioral assay for rodents and it has been
validated to assess the anti-anxiety effects of pharmacological agents and steroid hormones …

The ten-eleven translocation (Tet) family of methylcytosine dioxygenases catalyze oxidation
of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) and promote DNA …

Dr. Jacqueline N. Crawley, author of the First and Second Editions of What's Wrong with My
Mouse? Behavioral Phenotyping of Transgenic and Knockout Mice, continues to field calls …

CNS deletion of Pten in the mouse has revealed its roles in controlling cell size and number,
thus providing compelling etiology for macrocephaly and Lhermitte-Duclos disease. PTEN …

The plus-maze, the light–dark box and the open-field are the main current tests of
unconditioned anxiety for mice and rats. Despite their disappointing achievements, they …

Inhibitory neurotransmission in the brain is largely mediated by GABA A receptors.
Potentiation of GABA receptor activation through an allosteric benzodiazepine (BZ) site …

In the field of anxiety research, animal models are used as screening tools in the search for
compounds with therapeutic potential and as simulations for research on mechanisms …