The hippocampus hosts the continuous addition of new neurons throughout life—a
phenomenon named adult hippocampal neurogenesis (AHN). Here we revisit the …

The gene-regulatory landscape of the brain is highly dynamic in health and disease,
coordinating a menagerie of biological processes across distinct cell types. Here, we …

Tau aggregation in neurofibrillary tangles (NFTs) is closely associated with
neurodegeneration and cognitive decline in Alzheimer's disease (AD). However, the …

Neuroanatomists have long speculated that expanded primate brains contain an increased
morphological diversity of inhibitory neurons (INs), and recent studies have identified …

The development of insoluble, intracellular neurofibrillary tangles composed of the
microtubule-associated protein tau is a defining feature of tauopathies, including Alzheimer's …

Quantitative characterization of protein abundance and interactions in live cells is necessary
to understand and predict cellular behavior. The accurate determination of copy number for …

Imbalance of neuronal proteostasis associated with misfolding and aggregation of Tau
protein is a common neurodegenerative feature in Alzheimer's disease (AD) and other …

Multiplex single-molecule fluorescent in situ hybridization (smFISH) is a powerful method for
validating RNA sequencing and emerging spatial transcriptomic data, but quantification …

Nuclear exclusion of the RNA-and DNA-binding protein TDP-43 can induce
neurodegeneration in different diseases. Diverse processes have been implicated to …

Engulfment of cellular material and proteins is a key function for microglia, a resident
macrophage of the central nervous system (CNS). Among the techniques used to measure …