Enzymes catalyze biochemical reactions and play critical roles in human health and
disease. Enzyme variants and deficiencies can lead to variable expression of glycans, which …

Mucins represent a largely untapped class of polymeric building block for biomaterials,
therapeutics, and other biotechnology. Because the mucin polymer backbone is genetically …

Mucin-domain glycoproteins are densely O-glycosylated and play critical roles in a host of
biological functions. In particular, the T cell immunoglobulin and mucin-domain containing …

High-field asymmetric waveform ion mobility spectrometry (FAIMS) separates glycopeptides
in the gas phase prior to mass spectrometry (MS) analysis, thus offering the potential to …

ABO blood group antigens, which are complex carbohydrate moieties, and the first human
polymorphisms identified, are critical in transfusion medicine and transplantation. Despite …

Plate‐based single‐cell glycan and RNA sequencing (scGR‐seq) is previously developed to
realize the integrated analysis of glycome and transcriptome in single cells. However, the …

Protein glycosylation, the covalent attachment of carbohydrate, or glycan, structures onto the
protein backbone, is one of the most complex and heterogeneous post-translational …

A “state of the Art” lecture titled “Hemostatic Defects in Congenital Disorders of
Glycosylation” was presented at the ISTH 2022 congress. Congenital disorders of …

Abstract Changes in surface glycan determinants, specifically sialic acid loss, determine
platelet life span. The gradual loss of stored platelet quality is a complex process that …

Background Mechanical circulatory support (MCS) is a mainstay of therapy for advanced
and end-stage heart failure. Accompanied by systemic anticoagulation, contemporary MCS …