The E factor at 30: a passion for pollution prevention

RA Sheldon - Green Chemistry, 2023 - pubs.rsc.org
The introduction of the E Factor in 1992 focussed attention on the problem of waste
generation, defined as everything but the desired product, in chemicals manufacture and …

Shortening synthetic routes to small molecule active pharmaceutical ingredients employing biocatalytic methods

S Simić, E Zukić, L Schmermund, K Faber… - Chemical …, 2021 - ACS Publications
Biocatalysis, using enzymes for organic synthesis, has emerged as powerful tool for the
synthesis of active pharmaceutical ingredients (APIs). The first industrial biocatalytic …

Role of biocatalysis in sustainable chemistry

RA Sheldon, JM Woodley - Chemical reviews, 2018 - ACS Publications
Based on the principles and metrics of green chemistry and sustainable development,
biocatalysis is both a green and sustainable technology. This is largely a result of the …

The Hitchhiker's guide to biocatalysis: recent advances in the use of enzymes in organic synthesis

RA Sheldon, D Brady, ML Bode - Chemical science, 2020 - pubs.rsc.org
Enzymes are excellent catalysts that are increasingly being used in industry and academia.
This perspective is primarily aimed at synthetic organic chemists with limited experience …

Broadening the scope of biocatalysis in sustainable organic synthesis

RA Sheldon, D Brady - ChemSusChem, 2019 - Wiley Online Library
This Review is aimed at synthetic organic chemists who may be familiar with organometallic
catalysis but have no experience with biocatalysis, and seeks to provide an answer to the …

Biocatalysis: A pharma perspective

JP Adams, MJB Brown… - Advanced Synthesis …, 2019 - Wiley Online Library
Biocatalysis over the past few years has matured into an essential tool for modern, cost
effective and sustainable pharmaceutical manufacturing. While some reaction classes are …

The limits to biocatalysis: pushing the envelope

RA Sheldon, D Brady - Chemical communications, 2018 - pubs.rsc.org
In the period 1985 to 1995 applications of biocatalysis, driven by the need for more
sustainable manufacture of chemicals and catalytic,(enantio) selective methods for the …

Design and evolution of enzymes for non-natural chemistry

SC Hammer, AM Knight, FH Arnold - Current Opinion in Green and …, 2017 - Elsevier
Enzymes are used in biocatalytic processes for the efficient and sustainable production of
pharmaceuticals, fragrances, fine chemicals, and other products. Most bioprocesses exploit …

Accelerating the implementation of biocatalysis in industry

JM Woodley - Applied Microbiology and Biotechnology, 2019 - Springer
Despite enormous progress in protein engineering, complemented by bioprocess
engineering, the revolution awaiting the application of biocatalysis in the fine chemical …

CLEAs, combi-CLEAs and 'smart'magnetic CLEAs: Biocatalysis in a bio-based economy

RA Sheldon - Catalysts, 2019 - mdpi.com
Biocatalysis has emerged in the last decade as a pre-eminent technology for enabling the
envisaged transition to a more sustainable bio-based economy. For industrial viability it is …