The biologically relevant coordination chemistry of iron and nitric oxide: electronic structure and reactivity

N Lehnert, E Kim, HT Dong, JB Harland… - Chemical …, 2021 - ACS Publications
Nitric oxide (NO) is an important signaling molecule that is involved in a wide range of
physiological and pathological events in biology. Metal coordination chemistry, especially …

Reversing nitrogen fixation

N Lehnert, HT Dong, JB Harland, AP Hunt… - Nature Reviews …, 2018 - nature.com
The nitrogen cycle is one of the most important biogeochemical cycles on Earth because
nitrogen is an essential nutrient for all life forms. To supplement natural nitrogen fixation …

Biology and medicine in the landscape of quantum advantages

BA Cordier, NPD Sawaya… - Journal of the …, 2022 - royalsocietypublishing.org
Quantum computing holds substantial potential for applications in biology and medicine,
spanning from the simulation of biomolecules to machine learning methods for subtyping …

Nitric oxide in cellular adaptation and disease

BN Gantner, KM LaFond, MG Bonini - Redox Biology, 2020 - Elsevier
Nitric oxide synthases are the major sources of nitric oxide, a critical signaling molecule
involved in a wide range of cellular and physiological processes. These enzymes comprise …

Heme: emergent roles of heme in signal transduction, functional regulation and as catalytic centres

T Shimizu, A Lengalova, V Martínek… - Chemical Society …, 2019 - pubs.rsc.org
Protoporphyrin IX iron complex (heme) is an important cofactor for oxygen transfer, oxygen
storage, oxygen activation, and electron transfer when bound to the heme proteins …

Performance of Fe–N/C Oxygen Reduction Electrocatalysts toward NO2, NO, and NH2OH Electroreduction: From Fundamental Insights into the Active Center to a …

D Malko, A Kucernak, T Lopes - Journal of the American Chemical …, 2016 - ACS Publications
Although major progress has recently been achieved through ex situ methods, there is still a
lack of understanding of the behavior of the active center in non-precious metal Fe–N/C …

Physiological activation and deactivation of soluble guanylate cyclase

BG Horst, MA Marletta - Nitric Oxide, 2018 - Elsevier
Soluble guanylate cyclase (sGC) is responsible for transducing the gaseous signaling
molecule nitric oxide (NO) into the ubiquitous secondary signaling messenger cyclic …

NO/H2S “Crosstalk” Reactions. The Role of Thionitrites (SNO) and Perthionitrites (SSNO)

JP Marcolongo, MF Venancio, WR Rocha… - Inorganic …, 2019 - ACS Publications
The redox chemistry of H2S with NO and other oxidants containing the NO group is
discussed on a mechanistic basis because of the expanding interest in their biological …

Synthesis, characterization and reactivity of non-heme 1st row transition metal-superoxo intermediates

H Noh, J Cho - Coordination Chemistry Reviews, 2019 - Elsevier
Metalloenzymes activate dioxygen to generate metal-oxygen adducts that perform a wide
range of biological functions. Among the metal-dioxygen intermediates, highly reactive metal …

Mechanism of N–N Bond Formation by Transition Metal–Nitrosyl Complexes: Modeling Flavodiiron Nitric Oxide Reductases

C Van Stappen, N Lehnert - Inorganic Chemistry, 2018 - ACS Publications
Nitric oxide (NO) has a number of important biological functions, including nerve signaling
transduction, blood pressure control, and, at higher concentrations, immune defense. A …