Polycomb complexes regulate cell type–specific gene expression programs through
heritable silencing of target genes. Trimethylation of histone H3 lysine 27 (H3K27me3) is …

Aging is a multifactorial process that disturbs homeostasis, increases disease susceptibility,
and ultimately results in death. Although the definitive set of molecular mechanisms …

Mutating replication-dependent (RD) histone genes is an important tool for understanding
chromatin-based epigenetic regulation. Deploying this tool in metazoans is particularly …

Production of large amounts of histone proteins during S phase is critical for proper
chromatin formation and genome integrity. This process is achieved in part by the presence …

The histone locus body (HLB) assembles at replication-dependent (RD) histone loci and
concentrates factors required for RD histone mRNA biosynthesis. The Drosophila …

Despite binding similar cis elements in multiple locations, a single transcription factor (TF)
often performs context-dependent functions at different loci. How factors integrate cis …

Mono-methylation of histone H4 lysine 20 (H4K20me1) is catalyzed by Set8/KMT5A and
regulates numerous aspects of genome organization and function. Loss-of-function …

Despite binding similar cis elements in multiple locations, a single transcription factor often
performs context-dependent functions at different loci. How factors integrate cis sequence …

Tight control over cell identity gene expression is necessary for proper adult form and
function. The opposing activities of Polycomb and trithorax complexes determine the …

Histone post-translational modifications (PTMs) regulate processes necessary for gene
regulation, cell proliferation, and animal development by modulating DNA accessibility and …